MORG1
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Official Full Name
WDR83 WD repeat domain 83 -
Overview
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. -
Synonyms
MORG1;MGC4238;WD repeat domain-containing protein 83;MAPK organizer 1;mitogen-activated protein kinase organizer 1
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Involved Pathway
MORG1 involved in several pathways and played different roles in them. We selected most pathways MORG1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MORG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
MORG1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MORG1 itself. We selected most functions MORG1 had, and list some proteins which have the same functions with MORG1. You can find most of the proteins on our site.
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Interacting Protein
MORG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MORG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MORG1.
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References
- Loeffler, I; Wolf, G; et al. The role of hypoxia and Morg1 in renal injury. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 45:294-302(2015).
- Boggiatto, PM; Martinez, PA; et al. Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold. MICROBES AND INFECTION 16:328-336(2014).
