MNT
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Official Full Name
MAX binding protein -
Overview
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. -
Synonyms
MNT;MAX binding protein;max-binding protein MNT;bHLHd3;MAD6;Max interacting protein;MXD6;myc antagonist;ROX;Myc antagonist MNT;Max binding protein MNT;OTTHUMP00000115723;Max-interacting protein;class D basic helix-loop-helix protein 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MNT-9937M | Recombinant Mouse MNT Protein | Mammalian Cells | Mouse | His |
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| MNT-412HCL | Recombinant Human MNT lysate | HEK293 | Human | Non |
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| MNT-5449H | Recombinant Human MNT Protein, GST-tagged | Wheat Germ | Human | GST |
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| MNT-5615M | Recombinant Mouse MNT Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MNT-5615M-B | Recombinant Mouse MNT Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MNT-6288HF | Recombinant Full Length Human MNT Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 582 amino acids |
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Involved Pathway
MNT involved in several pathways and played different roles in them. We selected most pathways MNT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
MNT has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MNT itself. We selected most functions MNT had, and list some proteins which have the same functions with MNT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | DLX3,HMGB1A,ASH1L,YBX1,HMGB3B,EGFR,FOS,ATF2,HMGXB4,HMGB1 |
| transcription factor activity, sequence-specific DNA binding | ZNF205,ZBTB48,CTNNB1,MYCLB,TRP53,GATAD2AB,NR4A2B,SKINT8,PTF1A,HOXB6A |
| transcription coactivator activity | SUPT3H,ACTL6B,NCOA1,CCAR1,SMARCC2,NACA,CDK7,HCFC1,SETD3,PMF1 |
| transcription corepressor activity | JUB,BHLHE40,RYBP,C1D,ATF5,NEUROD2,SMYD1,SKI,NR0B2A,ELK3 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ONECUT3,MEF2A,ZNF711,BCL6,TRP53,ZNF548,NFKB1,IRF2,RELA,ZNF792 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | PCGF6,ZNF350,MSX1,DMBX1,GLIS1,HMX1,JARID2,ETV7,KLF6A,BCL6A |
| protein dimerization activity | TFE3,STAT5B,MYCA,SRFA,TFEC,BTRC,MYO5A,HER5,HER7,HNF1BA |
Interacting Protein
MNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MNT here. Most of them are supplied by our site. Hope this information will be useful for your research of MNT.
Dlg4;MLX;Max
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References
- Bin, BH; Bhin, J; et al. Hyperosmotic Stress Reduces Melanin Production by Altering Melanosome Formation. PLOS ONE 9:-(2014).
- Koumarianou, E; Slastnikova, TA; et al. Radiolabeling and in vitro evaluation of Ga-67-NOTA-modular nanotransporter - A potential Auger electron emitting EGFR-targeted radiotherapeutic. NUCLEAR MEDICINE AND BIOLOGY 41:441-449(2014).
