MMP25
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Official Full Name
matrix metallopeptidase 25 -
Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008] -
Synonyms
MMP25;matrix metallopeptidase 25;MMP20;MMPL1;MMP-25;MMP20A;MT6MMP;MTMMP6;MT-MMP6;MT6-MMP;MT-MMP 6;matrix metalloproteinase-25;leukolysin;matrix metalloproteinase 20;matrix metalloproteinase 25;matrix metallopeptidase-like 1;matrix metalloproteinase-like 1;membrane-type 6 matrix metalloproteinase;membrane-type matrix metalloproteinase 6;membrane-type-6 matrix metalloproteinase
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MMP25-9921M | Recombinant Mouse MMP25 Protein | Mammalian Cell | Mouse | His |
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| MMP25-1775H | Recombinant Human MMP25 protein, His-tagged | E.coli | Human | His | Tyr108~Ile313 |
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| MMP25-5605M | Recombinant Mouse MMP25 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MMP25-5605M-B | Recombinant Mouse MMP25 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RFL28219MF | Recombinant Full Length Mouse Matrix Metalloproteinase-25(Mmp25) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (163-593) |
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Involved Pathway
MMP25 involved in several pathways and played different roles in them. We selected most pathways MMP25 participated on our site, such as Matrix Metalloproteinases, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Matrix Metalloproteinases | MMP27,TIMP2,MMP24,MMP12,MMP17,MMP15,MMP26,BSG,MMP28,MMP23B |
Protein Function
MMP25 has several biochemical functions, for example, calcium ion binding,hydrolase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP25 itself. We selected most functions MMP25 had, and list some proteins which have the same functions with MMP25. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF266,ITGB1BP3,Trl,NEURL1AA,GNA12,ZSCAN18,CYP2AA8,CYP2AA3,ZHX3,RAB11FIP4A |
| hydrolase activity | TDRD12,KLK1B24,ATP9A,LIPM,HDAC7,BPHL,DPYSL5B,PSMA6B,PTPRUB,MEIOB |
| peptidase activity | NAALADL1,METAP2B,UNC5CL,TMPRSS5,HE2,CASPBL,ELA3L,TMPRSS4B,KLK1B3,MMP14A |
| metalloendopeptidase activity | MBTPS2,TLL2,YME1L1,MMP11,Adam6,ADAMTS13,MMP12,BMP1A,ADAMTS8,PAPLN |
| metallopeptidase activity | BRCC3,BMP1,ACE,CLCA2,CPD,XPNPEP3,GM12824,ADAM30,ANPEP,DPP3 |
| zinc ion binding | KLF4,APOBEC2A,MT1M,TIMM13,DPYS,RANBP2,TRIM28,RXRG,KDM5A,KDM4A |
| calcium ion binding | PROS1,SLC24A2,DOC2B,CDH13,EHD1A,F7,PCDH1GC6,MAN1A1,PCDH15B,PKD2L2 |
| peptidase activator activity | PSME4,FN1,MMP14,FBLN1,APP,CAV1,PINK1,PCOLCE,CLPX,PCOLCE2 |
Interacting Protein
MMP25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP25 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP25.
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