MMP24

  • Official Full Name

    matrix metallopeptidase 24 (membrane-inserted)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]

  • Synonyms

    MMP24;matrix metallopeptidase 24 (membrane-inserted);MMP25;MMP-24;MT5MMP;MTMMP5;MT-MMP5;MT5-MMP;MT-MMP 5;matrix metalloproteinase-24;membrane-type 5 matrix metalloproteinase;membrane-type matrix metalloproteinase 5;membrane-type-5 matrix metalloproteinase;matrix metalloproteinase 24 (membrane-inserted)

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&Myc
  • His&Fc&Avi

    Involved Pathway

    MMP24 involved in several pathways and played different roles in them. We selected most pathways MMP24 participated on our site, such as Activation of Matrix Metalloproteinases,Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Extracellular matrix organization FBLN2,DMD,MMP8,CTSK,LOXL2,BGNA,LOXL4,MFAP1,FAM49BA,MUSK
    Activation of Matrix Metalloproteinases MMP10,MMP17,CTRB1,FURINB,TIMP2B,MMP15,MGC174155,FURINA,MMP13,MMP8
    Degradation of the extracellular matrix MMP8,MGC174155,ADAM9,ADAMTS18,COL25A1,MGC174152,TPSAB1,ADAM8A,TLL2,ELANE
    Matrix Metalloproteinases MMP12,MMP8,MMP11,MMP27,MMP15,MMP23B,MMP26,MMP17,TIMP4,TIMP2

    Protein Function

    MMP24 has several biochemical functions, for example, cadherin binding,calcium ion binding,enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP24 itself. We selected most functions MMP24 had, and list some proteins which have the same functions with MMP24. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity MEP1A.2,ADAM9,ADAMTSL5,ADAM18,ADAMTS15A,YME1L1B,MMP2,MME,ADAM23,SPG7
    calcium ion binding FREM1A,MBL2,EHD1,UMODL1,SULF2B,CABP2,CAPNS1,PCDH18B,ACTN3A,PCDHA8
    zinc ion binding LHX9,MAN2B1,ADAM9,NEURL3,ESRRGB,TRIM24,JHDM1D,RABGEF1,OTUD7B,TRIM35-28
    cadherin binding CTNNB1,TBC1D2,PROM1,GNA13A,VCL,CDK5R1,NUMB,Fert2,FXYD5,JUPA
    enzyme activator activity MGST2,APOA5,SFTPB,GTF3C4,RICTOR,GLC8,TRIM23,SEC14L2,PPP1R12B,DNMT3L

    Interacting Protein

    MMP24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP24 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP24.

    Gorasp2

    Resources

    Gene Families

    What Is Matrix Metallopeptidase

    Research Area

    Metalloproteases and Regulators

    References

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