MMP17
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Official Full Name
matrix metallopeptidase 17 (membrane-inserted) -
Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008] -
Synonyms
MMP17;matrix metallopeptidase 17 (membrane-inserted);MT4-MMP;matrix metalloproteinase-17;MMP-17;MT4MMP;MTMMP4;MT-MMP 4;membrane-type matrix metalloproteinase 4;membrane-type-4 matrix metalloproteinase;matrix metalloproteinase 17 (membrane-inserted)
Recombinant Proteins
- Human
- Mouse
- Mammalian cells
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MMP17-26H |
Active Recombinant Human MMP17 protein, His-tagged
|
Mammalian cells | Human | His | 39-531 a.a. |
|
| MMP17-27H | Recombinant Human MMP17 protein | E.coli | Human | Non |
|
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| MMP17-609H | Recombinant Human MMP17, Catalytic Domain, His-tagged | E.coli | Human | His |
|
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| MMP17-9912M | Recombinant Mouse MMP17 Protein | Mammalian Cell | Mouse | His |
|
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| MMP17-3489H | Recombinant Human MMP17 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| MMP17-3489H-B | Recombinant Human MMP17 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| MMP17-5601M | Recombinant Mouse MMP17 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| MMP17-5601M-B | Recombinant Mouse MMP17 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
MMP17 involved in several pathways and played different roles in them. We selected most pathways MMP17 participated on our site, such as Activation of Matrix Metalloproteinases,Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Matrix Metalloproteinases | CTSL2,TIMP2A,CTSLL,TPSAB1,MMP11,CMA1,MMP15,CTRB1,ELANE,MMP8 |
| Matrix Metalloproteinases | MMP27,MMP12,TIMP2,MMP19,MMP23B,MMP10,MMP20,MMP24,TIMP4,MMP15 |
| Degradation of the extracellular matrix | CMA1,TLDC2,MMP11,BMP1,ADAMTS8,TPSAB1,BSG,MMP12,CTSK,CTSL2 |
| Extracellular matrix organization | BMP10,ADAMTS2,DMP1,TLL1,DAG1,JAM2B,LEPRE1,MGC174152,COL4A5,COL4A4 |
Protein Function
MMP17 has several biochemical functions, for example, calcium ion binding,enzyme activator activity,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP17 itself. We selected most functions MMP17 had, and list some proteins which have the same functions with MMP17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | CLPS,LTC4S,PSAPL1,MMP15,GLC8,CLPSL1,PRKCD,OGT,TRIM23,DCP1A |
| zinc ion binding | Car9,MAP3K7IP3,DPYS,CTCF,RFWD3,UBOX5,NR2C2,DNMT1,SHARPIN,ZNF385C |
| calcium ion binding | PDCD6,CCDC47,ANXA11,EPD,KCNIP1B,PEF1,EHD3,PLCH2,MMP13A,PCDH1G30 |
| metalloendopeptidase activity | HE2,GM12824,ADAM23,PITRM1,MMP23BB,THSD4,ADAM19,ADAM2,ADAMTS13,ADAMTS12 |
Interacting Protein
MMP17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP17 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP17.
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References
- Salz, T; Deng, CW; et al. Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer. MOLECULAR CANCER RESEARCH 13:461-469(2015).
- Wang, Y; Yu, SJ; et al. Expression and clinical significance of matrix metalloproteinase-17 and-25 in gastric cancer. ONCOLOGY LETTERS 9:671-676(2015).
