MLN
-
Official Full Name
motilin -
Overview
This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. -
Synonyms
MLN;motilin;prepromotilin;promotilin;MGC138519
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His&S
- His
- Non
- Myc&DDK
- His&GST&Myc
- His&Fc&Avi
- GST
Involved Pathway
MLN involved in several pathways and played different roles in them. We selected most pathways MLN participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | STAM2,USP9X,ARHGAP29,TLE3B,ARHGAP9,MDKA,OPN4B,ARHGAP25,MKL1,GDI2 |
| Class A/1 (Rhodopsin-like receptors) | DRD3,ADRA1B,OPN5,RLN3A,CCR6,NTS,OPN1LW2,HEBP1,RLN2,FPR-RS3 |
| GPCR ligand binding | SST,PENKB,ADM,NMB,OPN1MW,ADORA2A,CXCL11.8,PROK2,TAAR1,FFAR3 |
| Peptide ligand-binding receptors | SST1.1,INSL5,NMBA,INSL3,NTS,PRLH,ZFPM2B,TAC3,CX3CR1,SSTR1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | NPS,CCK,NMU,UTS2,OPN4B,GPR132B,KISS1,LPAR2B,LPAR5A,NMUR1 |
| Signaling by GPCR | ARHGEF25,PLEKHG2,FGD4A,ANXA1C,NTS,PROKR1A,GPR77,TAS2R16,TAS2R13,PNOC |
| GPCR downstream signaling | CXCR7B,GAL,OPN4.1,CCK,HRH3,GCGA,SSTR1,CXCR6,PTGDR2,CHRM2 |
| G alpha (q) signalling events | ARHGEF25,RASGRP2,QRFPR,PROKR1A,NMUR1,OPN4A,PRKCHB,DGKG,RGS18,TRPC3 |
Protein Function
MLN has several biochemical functions, for example, hormone activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLN itself. We selected most functions MLN had, and list some proteins which have the same functions with MLN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | IGF2A,PRLH,INHBA,IAPP,NPPB,TSHB,UCN3L,FSD1,IFNT2,INS |
| receptor binding | IDH1,GSTM7,PTK2B,FASLG,STRAP,RARRES2,CD2,LPL,PTK6,SNX17 |
Interacting Protein
MLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLN here. Most of them are supplied by our site. Hope this information will be useful for your research of MLN.
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References
- Andreassen, M; Bohn, T; et al. Cry1Ab Protein from Bacillus thuringiensis and MON810 cry1Ab-transgenic Maize Exerts No Adjuvant Effect After Airway Exposure. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:192-200(2015).
- Menard, S; Guzylack-Piriou, L; et al. Perinatal Exposure to a Low Dose of Bisphenol A Impaired Systemic Cellular Immune Response and Predisposes Young Rats to Intestinal Parasitic Infection. PLOS ONE 9:-(2014).
