MLLT4
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Official Full Name
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 -
Overview
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized. -
Synonyms
MLLT4;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 4;myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog);afadin;AF 6;AF6;protein AF-6;ALL1-fused gene from c
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- HEK293
- Non
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MLLT4-1011H | Recombinant Human MLLT4, Ras-binding Domain | E.coli | Human | Non |
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| MLLT4-29200TH | Recombinant Human MLLT4, GST-tagged | E.coli | Human | GST | 1-141 a.a. |
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| Mllt4-3234R | Recombinant Rat Mllt4, His-tagged | E.Coli/Yeast | Rat | His | 1829 |
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| MLLT4-3703R | Recombinant Rat MLLT4 Protein | Mammalian Cells | Rat | His |
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| MLLT4-9888M | Recombinant Mouse MLLT4 Protein | Mammalian Cells | Mouse | His |
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| MLLT4-3359R | Recombinant Rat MLLT4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| MLLT4-3359R-B | Recombinant Rat MLLT4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| MLLT4-5587M | Recombinant Mouse MLLT4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MLLT4-5587M-B | Recombinant Mouse MLLT4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MLLT4 involved in several pathways and played different roles in them. We selected most pathways MLLT4 participated on our site, such as Ras signaling pathway,Rap signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | IGF1,FGF20,PIK3CG,FGF8,PIK3R3,INSR,RAPGEF6,PARD6A,CDC42,VEGFA |
| Tight junction | JAM2,ACTN2,CLDN11B,MYL5,CDC42L,CLDNJ,GNAIA,MPDZ,VAPA,CLDN9 |
| Adherens junction | CDC42L2,RHOA,EP300,LEF1,ACTB,WASLA,ACTB1,SRC,PVRL1,SSX2IP |
| Leukocyte transendothelial migration | THY1,PIK3CB,CLDN15,PIK3R2,PRKCA,VASP,VCL,ITGB2,CLDN11,CDC42 |
| Ras signaling pathway | FLT4,FGF18,MAPK10,RRAS2,SHOC2,PIK3R5,PIK3CB,FGF22,RASSF5,PLD2 |
| cAMP signaling pathway | ROCK1,PLN,NPY,NFKBIA,BDNF,GRIN2B,NFATC1,FOS,PIK3R2,ATP2A2 |
Protein Function
MLLT4 has several biochemical functions, for example, Ras GTPase binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLLT4 itself. We selected most functions MLLT4 had, and list some proteins which have the same functions with MLLT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ras GTPase binding | SH3BP4,MAP2K1,RGL3,MAPKAP1,RAP1A,RIN1,RAP1GAP,RAPGEF4,SPHK2,RAPGEF6 |
| protein binding | GOLGA8G,CD151,SNAP25,GPR158,MAPRE3,PRICKLE1A,AKTIP,FBXO5,PRR16,LPA |
| protein C-terminus binding | CDC20,NCF2,VTA1,SIAH1,VPS36,HIC2,PCGF1,TERF2,DGKZ,RABAC1 |
Interacting Protein
MLLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLLT4.
SRC;PVRL3;YWHAG;PVRL2;LMO2;DBN1
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References
- Aalbers, AM; van den Heuvel-Eibrink, MM; et al. Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood. HAEMATOLOGICA 100:315-323(2015).
- Baird, JH; Minniti, CP; et al. Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide. BRITISH JOURNAL OF HAEMATOLOGY 168:737-746(2015).
