MLH3

  • Official Full Name

    mutL homolog 3 (E. coli)

  • Overview

    This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

  • Synonyms

    MLH3;mutL homolog 3 (E. coli);mutL (E. coli) homolog 3;DNA mismatch repair protein Mlh3;HNPCC 7;HNPCC;HNPCC7;MGC138372;Mismatch repair gene MLH 3;mismatch repair gene MLH3;MLH 3;MutL homolog 3;MutL protein homolog 3;S240II117
Cat.# Product name Source (Host) Species Tag Protein Length Price
MLH3-2782R Recombinant Rhesus monkey MLH3 Protein, His-tagged Mammalian Cells Rhesus macaque His
MLH3-4294HCL Recombinant Human MLH3 293 Cell Lysate HEK293 Human Non
MLH3-2603R Recombinant Rhesus Macaque MLH3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MLH3-2603R-B Recombinant Rhesus Macaque MLH3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    MLH3 involved in several pathways and played different roles in them. We selected most pathways MLH3 participated on our site, such as Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mismatch repair RPA3,MSH2,RFC3,POLD2,RPA2,RFC5,PMS2,MSH3,RFC1,POLD1

    Protein Function

    MLH3 has several biochemical functions, for example, ATP binding,ATPase activity,centromeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLH3 itself. We selected most functions MLH3 had, and list some proteins which have the same functions with MLH3. You can find most of the proteins on our site.

    Function Related Protein
    mismatched DNA binding MSH6,TDG,MSH4,PMS1,MSH5,MLH1
    ATP binding HSPA4,PINK1,LTK,MINK1,GPHN,UBE2D1,UBE2R2,TIMM44,UBE2KA,ERBB4
    centromeric DNA binding ZW10,MSH3,MSH2,CENPC1,CENPB,KIF2C
    chromatin binding HDGFRP2,PBRM1,NR5A5,SKOR2,NCOA3,KDM1A,TFAP2A,ERG,EGR2,JUN
    ATPase activity KIF3CB,HSP90AA1,ABCF2,KIF12,ABCG2A,ABCD1,ABCA5,KIF27,KIF1B,IDE
    satellite DNA binding CENPB,MBD4
    protein binding MRPL15,DDX41,ODC1,MRTO4,SMO,PDIA4,TAC3,HNRNPM,DPEP1,TTC3
    single-stranded DNA binding XPC,FUBP1,RTF1,RAD51D,HNRPDL,CNBPA,RAD51B,NABP2,NEIL3,PCBP1

    Interacting Protein

    MLH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLH3.

    FBP2;DVL1;CDC14B;CTSV;FRAT2;HRAS;TGFB1;ALDOB;FBP1;IGFBP3;RASA1;XPA;TMOD1;AKT1;HSD17B3;CDK8;STX17;SEC61B;PPP2CB;FANCC

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