MLC1
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Official Full Name
megalencephalic leukoencephalopathy with subcortical cysts 1 -
Overview
The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
MLC1;megalencephalic leukoencephalopathy with subcortical cysts 1;membrane protein MLC1;KIAA0027;LVM;MLC;VL
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- HEK293
- Mammalian Cells
- Non
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MLC1-3927H |
Active Recombinant Human MLC1 Full Length Transmembrane protein(Nanodisc)
|
HEK293 | Human | Non | Full L. |
|
| MLC1-2779R | Recombinant Rhesus monkey MLC1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
|
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| MLC1-5980Z | Recombinant Zebrafish MLC1 | Mammalian Cells | Zebrafish | His |
|
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| MLC1-9872M | Recombinant Mouse MLC1 Protein | Mammalian Cells | Mouse | His |
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| MLC1-2600R | Recombinant Rhesus Macaque MLC1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| MLC1-2600R-B | Recombinant Rhesus Macaque MLC1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| MLC1-5577M | Recombinant Mouse MLC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MLC1-5577M-B | Recombinant Mouse MLC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MLC1 involved in several pathways and played different roles in them. We selected most pathways MLC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MLC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MLC1 has several biochemical functions, for example, NOT ion channel activity,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLC1 itself. We selected most functions MLC1 had, and list some proteins which have the same functions with MLC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MKI67,RORC,IFT20,MRPL49,SPRYD7,MFN1,AKIP1,ADCYAP1,NVL,C1orf111 |
| protein complex binding | FBLN1,RARB,HADHA,AKAP5,SREBF1,ERCC6,MAPK8IP2,CDK5RAP2,MTHFR,SKIL |
| protein transporter activity | SOSTDC1B,USO1,VPS26A,AP4B1,RANGRF,KPNB3,TMCO6,CHMP7,AP3S2,AP2A1 |
| NOT ion channel activity | CCDC109B |
Interacting Protein
MLC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLC1.
Resources
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References
- Masaki, K; Suzuki, SO; et al. Extensive loss of connexins in Bal's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction. ACTA NEUROPATHOLOGICA 123:887-900(2012).
- Gundlach, CW; Caivano, A; et al. Synthesis and Evaluation of an Anti-MLC1 x Anti-CD90 Bispecific Antibody for Targeting and Retaining Bone-Marrow-Derived Multipotent Stromal Cells in Infarcted Myocardium. BIOCONJUGATE CHEMISTRY 22:1706-1714(2011).
