MKNK1
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Official Full Name
MAP kinase interacting serine/threonine kinase 1 -
Overview
Mitogen-activated protein kinases (MAPKs) are activated by various extracellular signals and play crucial roles in regulating cell proliferation, differentiation, survival, and apoptosis (1). MAPK-interacting kinases (Mnks or MKNKs) are direct downstream -
Synonyms
MKNK1;MAP kinase interacting serine/threonine kinase 1;MAP kinase-interacting serine/threonine-protein kinase 1;MNK1;MAPK signal-integrating kinase 1;MAP kinase signal-integrating kinase 1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Sf9 Cells
- Mammalian Cells
- Insect Cells
- HEK293
- Sf21 Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- Non
- His
- Flag
- DDK&Myc
- Avi&Fc&His
Involved Pathway
MKNK1 involved in several pathways and played different roles in them. We selected most pathways MKNK1 participated on our site, such as MAPK signaling pathway,HIF- signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKNK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | ARNT,PFKFB3,PLCG2,PDK1,TF,VHL,EIF4E1B,MAPK3,PRKCB,IGF1R |
| Insulin signaling pathway | PRKAB1A,IRS2,SOCS1,BADB,PPP1R3D,PRKAG3,RPS6KB1,PRKAA2,INSR,LIPE |
| MAPK signaling pathway | LAMTOR3,PRKACBA,FGF13B,FGF5,BDNF,MAPK12A,Pdgfa&Pdgfb,ATF4,SRF,TGFB3 |
Protein Function
MKNK1 has several biochemical functions, for example, ATP binding,calcium-dependent protein serine/threonine kinase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKNK1 itself. We selected most functions MKNK1 had, and list some proteins which have the same functions with MKNK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MYLK,RIT2,MARCKSL1A,MYO5A,RYR1,MKNK2,IQCB1,MYO1E,UBR4,NETO2 |
| protein serine/threonine kinase activity | AURKA,FASTK,PRKACAB,SNRKB,DCKL1B,NEK1,TBK1,SLKA,SMOK2B,DMPK |
| ATP binding | RUNX2,KIF11,ATP1A1A.4,SYN3,CHD4A,PPP2R4,FYNA,XRCC3,ACVR1,HELQ |
| calcium-dependent protein serine/threonine kinase activity | CAMK4,CAMK1GB,MAPKAPK5,CAMK1GA,DCX,MKNK2,MAPKAPK2A,MAPKAPK2B,MKNK2B,MKNK2A |
| calmodulin-dependent protein kinase activity | CAMK4,PTK2B,CAMK1GB,DAPK2A,MYLK3,CAMK1G,CAMK2G1,MYLK2,SLC14A2,MKNK2B |
| protein binding | INCENP,PGK1,TBX6,UBAP1,AP1G2,Aatk,DNM1L,SHOX,TSNAX,NDUFB9 |
Interacting Protein
MKNK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKNK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKNK1.
MAPK14;PPP2CA;EIF4E;EIF4G1;PAK2;HGS;EIF4G3;DDAH2;HSP90AB1;UBE2D1;ATXN3;PRKDC;TNIP2;CREBBP
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