MKKS
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Official Full Name
McKusick-Kaufman syndrome -
Overview
This gene encodes a protein with sequence similarity to the chaperonin family. The encoded protein may have a role in protein processing in limb, cardiac and reproductive system development. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6 and McKusick-Kaufman syndrome. Two transcript variants encoding the same protein have been identified for this gene. -
Synonyms
MKKS;McKusick-Kaufman syndrome;BBS6;McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin;Bardet Biedl syndrome 6 protein;HMCS;KMS;McKusick Kaufman syndrome;McKusick Kaufman/Bardet Biedl syndromes putative chaperonin;MKS;bardet-Biedl syndrome 6 protein
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Chicken
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MKKS-10512Z | Recombinant Zebrafish MKKS | Mammalian Cells | Zebrafish | His |
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| MKKS-2777R | Recombinant Rhesus monkey MKKS Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MKKS-4284C | Recombinant Chicken MKKS | Mammalian Cells | Chicken | His |
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| MKKS-726H | Recombinant Human MKKS | Mammalian Cells | Human | His |
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| MKKS-1114HCL | Recombinant Human MKKS cell lysate | Human | Non |
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| MKKS-2598R | Recombinant Rhesus Macaque MKKS Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| MKKS-2598R-B | Recombinant Rhesus Macaque MKKS Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| MKKS-3478H | Recombinant Human MKKS Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| MKKS-3478H-B | Recombinant Human MKKS Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| MKKS-5362H | Recombinant Human MKKS Protein, GST-tagged | Wheat Germ | Human | GST |
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| MKKS-6276HF | Recombinant Full Length Human MKKS Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 570 amino acids |
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Involved Pathway
MKKS involved in several pathways and played different roles in them. We selected most pathways MKKS participated on our site, such as Assembly of the primary cilium,BBSome-mediated cargo-targeting to cilium,Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Organelle biogenesis and maintenance | WDR34,ICT1,TTC30A2,GABPB1,PPRC1,MRPS28,BBS9,LZTFL1,BBS5,BBS7 |
| Cargo trafficking to the periciliary membrane | CNGA5,CCT8,ARL3,NPHP3,BBS10,BBS12,ARF4,EXOC3,ARF4A,UNC119.1 |
| BBSome-mediated cargo-targeting to cilium | LZTFL1,BBS4,CCT4,CCT3,BBS7,BBS10,CCT2,CCT8,BBS1,TTC8 |
| Assembly of the primary cilium | HSPB11,ARF4,FLR,EXOC3,CEP76,CCT8,HAUS2,CEP164,CNGA5,CCT2 |
Protein Function
MKKS has several biochemical functions, for example, ATP binding,RNA polymerase II repressing transcription factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKKS itself. We selected most functions MKKS had, and list some proteins which have the same functions with MKKS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | TOMM20,PFDN5,SPG7,DNAJB6,CALR3,TBCA,CCDC102A,TCP1,GRXCR2,HSPA6 |
| ATP binding | ACTR1B,FARSA,IRAK1,KCNJ8,PSMC4,TAOK3,RHOBTB3,ENTPD1,UBE2L3B,FANCM |
| RNA polymerase II repressing transcription factor binding | GSC,TCF7L2,PROL1,PPARA,STAT3,BBS2,TBX5A,MTA1,RBBP8,BBS10 |
| protein binding | ATG9A,FAM110C,CRP,TXNRD1,APBA3,PODXL2,SNX1,DCAF11,SRI,BCL2L14 |
Interacting Protein
MKKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKKS here. Most of them are supplied by our site. Hope this information will be useful for your research of MKKS.
BBS7;BBS10;BBS12
Resources
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References
- Rao, KP; Vani, G; et al. Arsenic stress activates MAP kinase in rice roots and leaves. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 506:73-82(2011).
- Zhao, Y; Herdegen, T; et al. Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria. MOLECULAR AND CELLULAR NEUROSCIENCE 41:186-195(2009).
