MID2
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Official Full Name
midline 2 -
Overview
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. -
Synonyms
MID2;midline 2;probable E3 ubiquitin-protein ligase MID2;FXY2;RNF60;TRIM1;Midin-2;Midline defect 2;Midline-2;RING finger protein 60;Ring finger protein protein 60;TRIM1_HUMAN;Tripartite motif protein 1;Tripartite motif-containing protein 1;midin 2;OTTHUMP00000023816;OTTHUMP00000023817
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MID2-877H | Recombinant Human MID2, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| MID2-4318HCL | Recombinant Human MID2 293 Cell Lysate | HEK293 | Human | Non |
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| MID2-4319HCL | Recombinant Human MID2 293 Cell Lysate | HEK293 | Human | Non |
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| MID2-2443H | Recombinant Human MID2 Protein, His-tagged | E.coli | Human | His | Ser7-Glu258 |
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| MID2-5330H | Recombinant Human MID2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MID2-6588HF | Recombinant Full Length Human MID2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 685 amino acids |
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Involved Pathway
MID2 involved in several pathways and played different roles in them. We selected most pathways MID2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MID2 has several biochemical functions, for example, ligase activity,microtubule binding,phosphoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MID2 itself. We selected most functions MID2 had, and list some proteins which have the same functions with MID2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | WWP2,PJA1,UBR7,COP1,MEX3C,MARCH9,TTC3,ZSWIM2,RNF220,MGRN1A |
| protein heterodimerization activity | LIMK1,VAPB,DR1,CUL3,GABRR1,TIMELESS,NFYBA,CHUK,POU5F3,BCL2 |
| zinc ion binding | TTC3,ZDHHC8B,TRIM8A,TRIM16,ZDHHC14,OTUD7B,RNF6,FHL1,RNF19B,EP300 |
| microtubule binding | PRC1,SYBU,NPSNL,DPYSL5B,EZR,TPPP,TRPV4,DCX,MAPRE2,FES |
| protein binding | KDM2B,BIRC2,ARHGEF10,COP1,PAIP2,TDO2,MAGEA4,S100A8,DESI1,SCN11A |
| phosphoprotein binding | ARR3,YWHAB,MID1,CACNB2,TBL2,PRKCSH,RB1,DPYS,SFN,PITX2 |
| protein homodimerization activity | PFKM,RAG1,AXIN1,ADSSL1,CD4,ATPIF1,NAGA,NCR3,NTSR1,CER1 |
Interacting Protein
MID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MID2.
COX5B;ZNF24;GFI1B;ligA;CEP57L1;DYDC1;TSGA10;TMEM14B;UBE2D4;TCAF1
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References
- Miyamoto, M; Furuichi, Y; et al. The high-osmolarity glycerol- and cell wall integrity-MAP kinase pathways of Saccharomyces cerevisiae are involved in adaptation to the action of killer toxin HM-1. YEAST 29:475-485(2012).
- Martin, H; Rodriguez-Pachon, JM; et al. Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae. JOURNAL OF BIOLOGICAL CHEMISTRY 275:1511-1519(2000).
