MGST3
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Official Full Name
microsomal glutathione S-transferase 3 -
Overview
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides. -
Synonyms
MGST3;microsomal glutathione S-transferase 3;GST III;microsomal glutathione S transferase III;microsomal GST 3;microsomal GST III;MGST3_HUMAN;Microsomal glutathione S transferase 3;Microsomal GST-3;Microsomal GST-III;Microsomal GST3;Microsomal GSTIII;microsomal glutathione S-transferase III;GST-III
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- Human
- Bovine
- Mus musculus
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
MGST3 involved in several pathways and played different roles in them. We selected most pathways MGST3 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGST3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - cytochrome P | UGT1A7C,ALDH3A1,FMO1,ALDH3B2,FMO6P,AOX4,UGT2B15,FMO2,GSTO1,UGT1A3 |
| Chemical carcinogenesis | ADH6,CHRNA7,CYP3A5,UGT1A2,ARNT,UGT1A4,CYP2C9,CYP2C70,GSTP2,CYP3A41B |
| Glutathione metabolism | GSTM6,GGT1,GPX1,GSTA,GPX4,GSTT1B,GSTM2,GSTM1,GSTM7,MGST2 |
| Metabolism of xenobiotics by cytochrome P | ALDH3B1,UGT1A6B,GSTAL,UGT1A4,UGT2A2,ALDH1A3,GSTM7,GSTP2,MGST1.2,EPHX1 |
Protein Function
MGST3 has several biochemical functions, for example, glutathione peroxidase activity,glutathione transferase activity,peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGST3 itself. We selected most functions MGST3 had, and list some proteins which have the same functions with MGST3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GSTP1,GSTM5,GSTK1,GSTA,GSTT1,MGST1,GSTZ1,GRX2,GSTM7,GSTT2B |
| glutathione peroxidase activity | GPX4A,CLIC2,GRX2,GPX2,GPX1B,MGST2,GPX4,GPX5,MGST1,GPX3 |
| protein binding | POSTN,EXD1,PCGF5,ZAP70,ZFAND6,NPY1R,TOX4,APLF,CCER1,MPP7 |
| peroxidase activity | MPX,GPX1A,MPO,TPO,PTGS2,GPX1B,GPX7,PRDX1,CYGB,GPX6 |
Interacting Protein
MGST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGST3.
CCNC;Tubb4b;F10;Lin7c;Rmdn3;VAPA;GOLT1B
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References
- Weng, ZQ; Greenhaw, J; et al. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. TOXICOLOGY LETTERS 214:328-338(2012).
- Bhattacharya, P; Keating, AF; et al. Protective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY 260:201-208(2012).
