MGST2
-
Official Full Name
microsomal glutathione S-transferase 2 -
Overview
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. -
Synonyms
MGST2;microsomal glutathione S-transferase 2;MGST II;FLJ27438;GST 2;GST2;MGC14097;MGST 2;MGSTII;Microsomal glutathione S transferase 2;Microsomal GST 2;Microsomal GST II;microsomal GST-2;microsomal GST-II;MGST-II
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Cynomolgus
- Human
- Bovine
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
MGST2 involved in several pathways and played different roles in them. We selected most pathways MGST2 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGST2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | ADH1,ADH1B,CYP2C70,CYP2C54,ALDH3B2,UGT1A4,MGST3,CYP2A6,SULT1A2,ADH5 |
| Metabolism of xenobiotics by cytochrome P | MGST3,HSD11B1,GSTM6,GSTA,UGT1A2,ALDH3A1,UGT1A6,CBR1,UGT2A3,AKR7A2 |
| Glutathione metabolism | MGST1.1,GSTM1,GSTP2,GSTK1,GPX8,GSS,LAP3,GSTA5,GGT1,GSTA3 |
| Drug metabolism - cytochrome P | FMO3,GSTA2,UGT1A4,MAOA,AOX3,GSTM3,UGT1A6B,GSTAL,GSTM,AOX3L1 |
Protein Function
MGST2 has several biochemical functions, for example, enzyme activator activity,glutathione peroxidase activity,glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGST2 itself. We selected most functions MGST2 had, and list some proteins which have the same functions with MGST2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GRX2,GSTO2,GSTA5,GSTT1B,GSTP1,GSTO1,GSTT2B,GSTAL,MGST1,LTC4S |
| glutathione peroxidase activity | MGST3,GPX1B,GPX3,GRX2,GPX4A,CLIC2,MGST1,GPX1A,GSTK1,PRDX6 |
| leukotriene-C4 synthase activity | LTC4S |
| enzyme activator activity | GLC8,CLPSL1,MMP24,DCP1A,TAB1,ARL1,APOA5,PSAPL1,SFTPB,OGT |
Interacting Protein
MGST2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGST2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGST2.
Resources
Related Services
Related Products
References
- Weng, ZQ; Greenhaw, J; et al. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. TOXICOLOGY LETTERS 214:328-338(2012).
- Bhattacharya, P; Keating, AF; et al. Protective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY 260:201-208(2012).
