MGAT4B

  • Official Full Name

    mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B

  • Overview

    This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.

  • Synonyms

    MGAT4B;mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B;mannosyl (alpha 1,3 ) glycoprotein beta 1,4 N acetylglucosaminyltransferase, isoenzyme B;alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B;GnT Ivb;Alpha 1 3 mannosyl glycoprotein beta 1 4 N acetylglucosaminyltransferase;Aminyltransferase;GlcNAc T IVb;GNT IV;GNTIV;GNTIVB;Mannosyl (alpha 1 3) glycoprotein beta 1 4 N acetylglucosaminyltransferase isozyme B;MGAT 4B;N acetylglucosaminyltransferase IVb;N glycosyl oligosaccharide glycoprotein;N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase IVb;UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IV;UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IVb;glcNAc-T IVb;N-acetylglucosaminyltransferase IVb;alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase;N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb;mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B;UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV;UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb;GNT-IV;GNT-IVB

Recombinant Proteins

  • Rhesus macaque
  • Zebrafish
  • Mouse
  • Human
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • E.coli
  • His
  • Non
  • GFP
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
MGAT4B-2761R Recombinant Rhesus monkey MGAT4B Protein, His-tagged Mammalian Cells Rhesus macaque His
MGAT4B-399Z Recombinant Zebrafish MGAT4B Mammalian Cells Zebrafish His
MGAT4B-9811M Recombinant Mouse MGAT4B Protein Mammalian Cells Mouse His
MGAT4B-4341HCL Recombinant Human MGAT4B 293 Cell Lysate HEK293 Human Non
MGAT4B-06H Recombinant Human MGAT4B Protein (AA 41-548), N-6×His/GFP tagged HEK293 Human GFP&His AA 41-548
MGAT4B-2582R Recombinant Rhesus Macaque MGAT4B Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MGAT4B-2582R-B Recombinant Rhesus Macaque MGAT4B Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MGAT4B-4365H Recombinant Human MGAT4B Protein, GST-tagged Wheat Germ Human GST
MGAT4B-5535M Recombinant Mouse MGAT4B Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MGAT4B-5535M-B Recombinant Mouse MGAT4B Protein Pre-coupled Magnetic Beads HEK293 Mouse
MGAT4B-6228HF Recombinant Full Length Human MGAT4B Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 563 amino acids
MGAT4B-7853H Recombinant Human MGAT4B protein, GST-tagged E.coli Human GST
MGAT4B-7854H Recombinant Human MGAT4B protein, His-tagged E.coli Human His

    Involved Pathway

    MGAT4B involved in several pathways and played different roles in them. We selected most pathways MGAT4B participated on our site, such as Asparagine N-linked glycosylation,Metabolic pathways,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    N-Glycan biosynthesis MGAT4A,ALG8,DPM2,MGAT4C,MGAT5B,B4GALT2,MGAT1A,RABGNT1,MGAT1B,B4GALT3
    Asparagine N-linked glycosylation NEU4,DDOST,TRAPPC10,MAGT1,NAPAA,ZNF408,CNIH3,ALG2,NANP,ST8SIA2
    Post-translational protein modification TRAPPC2,DPH1,SEC16B,TRAPPC4,ADAMTS20,ARSF,PPP6R1,ARSJ,GNE,ARSH
    Metabolism of proteins SEC22C,TUBA1B,ARSJ,THSD1,WIPI1,SMC5,PAM16,SEC16B,ACE,MUC12
    N-Glycan antennae elongation ST8SIA2,ST8SIA3,MGAT4A
    Transport to the Golgi and subsequent modification SEC16B,TRAPPC2,TRAPPC3,SEC23IP,ANKRD28,MIA3,TMED10,MCFD2,PPP6R3,NAPB
    N-glycan antennae elongation in the medial/trans-Golgi ST8SIA2,ST8SIA3,MGAT4A
    Metabolic pathways CYP4F3,ACSBG2,UPB1,RDH8,PYGL,MGAT3,APIP,RPE,PLA2G12B,CHPT1

    Protein Function

    MGAT4B has several biochemical functions, for example, alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT4B itself. We selected most functions MGAT4B had, and list some proteins which have the same functions with MGAT4B. You can find most of the proteins on our site.

    Function Related Protein
    alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity MGAT4A,MGAT4C,4931440L10Rik
    metal ion binding CYP19A1B,MICALL2A,EGLN1B,CSGALNACT2,PDE6C,PDE3A,ZNF274,DNAJC21,ZNF688,DMRTA1

    Interacting Protein

    MGAT4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT4B here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT4B.

    LRSAM1;bgaB

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