MFN1
-
Official Full Name
mitofusin 1 -
Overview
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008] -
Synonyms
MFN1;mitofusin 1;hfzo1;hfzo2;mitofusin-1;fzo homolog;transmembrane GTPase MFN1;putative transmembrane GTPase;mitochondrial transmembrane GTPase FZO-2;mitochondrial transmembrane GTPase Fzo-1
Recombinant Proteins
- Chicken
- Human
- Rhesus macaque
- Rat
- Mouse
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- DDK
- Myc
- T7
- Non
- Avi
- Fc
- Flag
- GST
Involved Pathway
MFN1 involved in several pathways and played different roles in them. We selected most pathways MFN1 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis,Mitophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with MFN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Factors involved in megakaryocyte development and platelet production | HMG20B,CENPE,KIF18A,HBBE1.1,MAFF,KIF4,MGC173646,HBE1,MFN2,ITPK1 |
| Mitophagy | LC3,TOMM70A,MFN2,TOMM40,TOMM20B,TOMM6,MTERFD1,TOMM22,TOMM5,TOMM7 |
| Pink/Parkin Mediated Mitophagy | MFN2,TOMM22,TOMM40,TOMM20,TOMM6,MAP1LC3B,TOMM20B,TOMM5,MTERFD1,LC3 |
| Hemostasis | ITPK1,TFA,DOCK10,OSTN,KIF4,ATP2B1B,KIF22,HBG1,APOER2,ATP2B3A |
Protein Function
MFN1 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MFN1 itself. We selected most functions MFN1 had, and list some proteins which have the same functions with MFN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RERGL,RAC2,LRRK1,ARL8BA,RAB31,RAB41,GNL1,RAB32A,EEF1A1A,RAB39A |
| protein binding | RPL30,C3orf52,GNG12,GJA1,POLD2,SUMO3,AKR1A1,RALY,KIAA0947,SNRPB |
| GTPase activity | SAR1B,GNGT1,RAB20,TBCC,GBP2,DNM1A,TUBB4A,GNAO1,RAB6C,RAB4A |
Interacting Protein
MFN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MFN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MFN1.
Bak1;TSC22D1;MAVS;TMBIM4;glmU;BAK1;PLK2
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