MEIS1
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Official Full Name
Meis homeobox 1 -
Overview
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE (three amino acid loop extension) family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008] -
Synonyms
MEIS1;Meis homeobox 1;homeobox protein Meis1;WUGSC:H_NH0444B04.1;leukemogenic homolog protein;Meis1, myeloid ecotropic viral integration site 1 homolog
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- Yeast
- E.coli
- GST
- Non
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MEIS1-26868TH | Recombinant Human MEIS1 protein, GST-tagged | Wheat Germ | Human | GST | 1-378 a.a. |
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| MEIS1-29559TH | Recombinant Human MEIS1 | Wheat Germ | Human | Non | 90 amino acids |
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| MEIS1-3886C | Recombinant Chicken MEIS1 | Mammalian Cells | Chicken | His |
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| MEIS1-9722M | Recombinant Mouse MEIS1 Protein | Mammalian Cells | Mouse | His |
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| MEIS1-4373HCL | Recombinant Human MEIS1 293 Cell Lysate | HEK293 | Human | Non |
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| MEIS1-1244H | Recombinant Human MEIS1 protein, His-tagged | Yeast | Human | His | 180-320aa |
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| MEIS1-4532H | Recombinant Human MEIS1 Protein (Asp200-Met334), N-His tagged | E.coli | Human | His | Asp200-Met334 |
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| MEIS1-5470M | Recombinant Mouse MEIS1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MEIS1-5470M-B | Recombinant Mouse MEIS1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MEIS1 involved in several pathways and played different roles in them. We selected most pathways MEIS1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEIS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | H3F3C,MDM2,HIST1H3C,IGFBP3,MLLT3,HIST3H3,ETV7,TGFBR2,NUPR1,ARNT2 |
| Signaling pathways regulating pluripotency of stem cells | IGF1,MAPK13,WNT7A,WNT9B,AKT1,HESX1,BMPR2,WNT6,FZD2,WNT10B |
Protein Function
MEIS1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEIS1 itself. We selected most functions MEIS1 had, and list some proteins which have the same functions with MEIS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | LEF1,CEBPB,NKX2-1,CIR1,SFPI1,RFX1,TLE4,RELA,NKX2,PTH |
| protein heterodimerization activity | CD3E,UGT1A6B,Itgam&Itgb2,SDCBP2,TOP2B,TAS1R1,TIRAP,KHDRBS2,WHRN,DMRT1 |
| protein binding | NLGN4X,DPP4,PDLIM4,CAMP,FGFR1,JDP2,TUBGCP2,RAD17,TSC22D3,DOLK |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MYBL2,TCF21,ARNT2,SMAD2,SREBF1,HIF1A,EBF4,GCM1,ETV6,ATF4 |
| chromatin binding | RNF2,SOX9A,SSBP1,DHX30,SREBF1,KIAA0101,TFAP2A,URI1,STAG2,PRKAA1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ALS2CR8,ZIC3,HNRNPK,POU2F2,TCF7L2,MYC,RBPJ,ATOH1,RBPJL,FIGLA |
Interacting Protein
MEIS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEIS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MEIS1.
CREB1;TLX1;ETS1;Creb1;TRMT10B;q8d1q5_yerpe;fos_mouse_gene;PBX1
Resources
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References
- Crist, RC; Roth, JJ; et al. A Conserved Tissue-Specific Homeodomain-Less Isoform of MEIS1 Is Downregulated in Colorectal Cancer. PLOS ONE 6:-(2011).
- Cvejic, A; Serbanovic-Canic, J; et al. The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 96:190-198(2011).
