MED9
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Official Full Name
mediator complex subunit 9 -
Overview
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. -
Synonyms
MED9;mediator complex subunit 9;mediator of RNA polymerase II transcription, subunit 9 homolog (S. cerevisiae);mediator of RNA polymerase II transcription subunit 9;FLJ10193;MED25;Mediator subunit 25;MGC138234;mediator of RNA polymerase II transcription, subunit 9 homolog
Recombinant Proteins
- Rhesus macaque
- Chicken
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
- Avi
- Fc
- GST
Involved Pathway
MED9 involved in several pathways and played different roles in them. We selected most pathways MED9 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPARA activates gene expression | MED21,SREBF2,G0S2,MTF1,MED10,MED29,MED8,GRHL1,MED16,ANKRD1 |
| Metabolism | CDIPT,CYP27B1,CKMT2,ARL2BP,ACAD11,SLC19A2,NDUFAF6,CYP4B1,NUDT16,UCP2 |
| Transcriptional regulation of white adipocyte differentiation | NR2F2,EGR2,MED18,CDK19,MED22,MED29,EBF1,MED21,MED19 |
| Metabolism of lipids and lipoproteins | AKR1B15,GDF1,CYP27A1,FIG4,NFYBA,SLC27A2,CPNE7,CYP2AD6,DHCR24,ESRRA |
| Fatty acid, triacylglycerol, and ketone body metabolism | TMEM195,SREBF2,APOA5,MED20,ACOT11B,YAP1,CCNC,CTGF,ACOT13,ACSF2 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED20,MED29,CDK19,MED16,MED6,G0S2,MED15,GRHL1,MED22,MED25 |
| Developmental Biology | DLG3,EFNA1A,NRP1A,CEBPB,JAK3,PEBP1,MYL12B,FGFR1B,RND1L,RNF8 |
Protein Function
MED9 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED9 itself. We selected most functions MED9 had, and list some proteins which have the same functions with MED9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED14,MED21,MED26,MED12,PPARGC1A,MDT-19,MED20,MED13L,MED17,RBM14 |
| protein binding | CLDN1,DCTPP1,HERC5,CLC,CCDC123,SYNE3,FYB,DDX39A,VHL,OCLN |
Interacting Protein
MED9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED9.
MED4;CDK8;MED10;MED21
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