MED7
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Official Full Name
mediator complex subunit 7 -
Overview
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
MED7;mediator complex subunit 7;cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa , CRSP9;mediator of RNA polymerase II transcription subunit 7;CRSP33;Activator recruited cofactor 34 kDa component;ARC34;Cofactor required for Sp1 transcriptional activation subunit 9;MGC12284;RNA polymerase transcriptional regulation mediator subunit 7 homolog;Transcriptional coactivator CRSP33;hMED7;OTTHUMP00000160735;CRSP complex subunit 9;activator-recruited cofactor 34 kDa component;RNA;CRSP9
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MED7-10132Z | Recombinant Zebrafish MED7 | Mammalian Cells | Zebrafish | His |
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| MED7-1910H | Recombinant Human MED7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MED7-26939TH | Recombinant Human MED7 | Human | Non | Full L. 1-233 a.a. |
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| MED7-9706M | Recombinant Mouse MED7 Protein | Mammalian Cells | Mouse | His |
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| MED7-4379HCL | Recombinant Human MED7 293 Cell Lysate | HEK293 | Human | Non |
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| MED7-1121H | Recombinant Human MED7 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MED7-2110HF | Recombinant Full Length Human MED7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 233 amino acids |
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| MED7-5462M | Recombinant Mouse MED7 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MED7-5462M-B | Recombinant Mouse MED7 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MED7 involved in several pathways and played different roles in them. We selected most pathways MED7 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | ZNF713,ZKSCAN5,ZNF597,ZNF560,RNF111,PPARAA,SKIA,ZNF202,ZNF490,ZNF2 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED31,MED26,MED29,MED19,CDK19,MED23,MED15,MED25,PLIN2,MED9 |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACOT11B,MED18,ACOT11,CYP4A11,CDK8,MED9,MTF1,G0S2,CTGF,PLIN2 |
| Metabolism | CBLC-1,GPHN,RHAG,KCNS3A,OAZ1A,PDP2,GC,CIAO1,GPHNA,COX16 |
| PPARA activates gene expression | TIAM2,MED23,G0S2,MED18,MED22,GRHL1,MED8,ANKRD1,CTGF,MED16 |
| Developmental Biology | CEBPB,ST8SIA2,SPTBN1,CDK8,EZRA,CFL1,SPTBN2,TCF4,PAQR3B,LGI3 |
| Metabolism of lipids and lipoproteins | ABHD4,PLIN2,APOF,ARSF,G0S2,AKR1C6,PLBD1,ACOT11,ALOX5B.3,SIN3B |
| Gene Expression | TRMT5,ZNF596,TACO1,CRCP,ZNF668,ZNF257,DDX20,RRAGB,EIF2C3,ZNF133 |
Protein Function
MED7 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,protein binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED7 itself. We selected most functions MED7 had, and list some proteins which have the same functions with MED7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED31,FOXH1,MED20,PPARGC1A,MED19B,RBM14,NKX2-5,MED13A,MED21,TDG |
| ubiquitin protein ligase activity | RNF144AB,UBE2N,HECTD1,UBR3,MARCH8,RNF4,FANCF,CMTM2A,RNF220,HECW1B |
| transcription coactivator activity | SMARCD1,PRRX1,ABT1,BRCA1,CREBBP,RXRB,RNF14,HIF3A,ENY2,HAND1 |
| protein binding | PPIA,HBA2,GSE1,FAH,F11R,PPM1A,DNAJC11,ZBTB48,VAT1L,TMEM27 |
Interacting Protein
MED7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED7.
MED10;MED26;MED19;env;CDK19;MED9
Resources
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References
- Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
- Sendler, M; Dummer, A; et al. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. GUT 62:430-439(2013).
