MED6

  • Official Full Name

    mediator complex subunit 6

  • Overview

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

  • Synonyms

    MED6;mediator complex subunit 6;ARC33;NY-REN-28;mediator of RNA polymerase II transcription subunit 6;CTD-2540L5.5;renal carcinoma antigen NY-REN-28;activator-recruited cofactor 33 kDa component

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • T7
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
MED6-131H Recombinant Human MED6 protein, T7-tagged E.coli Human T7 157 a.a.
MED6-316Z Recombinant Zebrafish MED6 Mammalian Cells Zebrafish His
MED6-3945C Recombinant Chicken MED6 Mammalian Cells Chicken His
MED6-557H Recombinant Human MED6 Protein, His-tagged E.coli Human His
MED6-841H Recombinant Human Mediator Complex Subunit 6, T7-tagged E.coli Human T7 1-157 a.a.
MED6-9705M Recombinant Mouse MED6 Protein Mammalian Cells Mouse His
MED6-4380HCL Recombinant Human MED6 293 Cell Lysate HEK293 Human Non
MED6-4466H Recombinant Human MED6 Protein, GST-tagged Wheat Germ Human GST
MED6-5461M Recombinant Mouse MED6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
MED6-5461M-B Recombinant Mouse MED6 Protein Pre-coupled Magnetic Beads HEK293 Mouse
MED6-6251HF Recombinant Full Length Human MED6 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 246 amino acids

    Involved Pathway

    MED6 involved in several pathways and played different roles in them. We selected most pathways MED6 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism MTF1,CEPT1A,FAAH2A,LPA,DAO1,APOEA,ARSH,ACSF2,BRP44,CKM
    Metabolism of lipids and lipoproteins HSD17B11,NFYBA,FA2H,AKR1B15,SIN3B,ABHD4,FABP11B,GGTLC1,ACOT8,ACSF2
    Developmental Biology SIAH2,WDR83,COL9A1,CLTB,KCNQ2,PEA15,POU5F3,EFNA3,ADAM23,ARPC4
    PPARA activates gene expression GRHL1,APOA5,MED7,MED18,TIAM2,MED31,MED8,CTGF,MED29,MED19
    Gene Expression NR5A1B,ZNF625,CBX3,ZNF543,NR1D2B,SAP130,RNF111,SF3B2,DCP2,SNRNP35
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED29,MED23,CDK19,CTGF,MED18,MED22,MED9,MED31,ANKRD1,MED25
    Fatty acid, triacylglycerol, and ketone body metabolism CCNC,ACOT9,MED9,ACSF2,CTGF,AGPAT2,ACOT9.1,SLC25A1A,MED31,MED18
    Generic Transcription Pathway ZNF697,ZNF71,NRBF2,NR2F1,SKILB,ZNF331,HBXIP,ZNF485,ZNF133,TUBB3

    Protein Function

    MED6 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly,protein binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED6 itself. We selected most functions MED6 had, and list some proteins which have the same functions with MED6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ZBTB32,FRMD8,KLF10,CD200R1,CCDC93,AKR7A3,HSPA4L,HSD17B12,MAP3K2,ATPAF1
    transcription factor binding CREG1,MDFIC,MED25,DIP2BA,DAXX,SUFU,SOX17,DR1,CRY1,TBX5
    transcription coactivator activity TCERG1,EP300,KDM5A,PCBD1,SUB1,EDF1,CITED2,ATXN7L3,SMARCB1,MLL5

    Interacting Protein

    MED6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED6.

    MED10;MED29;MED19;CDK19;MED26;CDK8

    Resources

    References

    • Ruiz, A; Pauls, E; et al. Characterization of the Influence of Mediator Complex in HIV-1 Transcription. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27665-27676(2014).
    • Lariviere, L; Plaschka, C; et al. Structure of the Mediator head module. NATURE 492:448-+(2012).

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