MED25
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Official Full Name
mediator complex subunit 25 -
Overview
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. -
Synonyms
MED25;mediator complex subunit 25;mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae);mediator of RNA polymerase II transcription subunit 25;ACID1;ARC92;DKFZp434K0512;TCBAP0758;Activator interaction domain 1 protein;Activator interaction domain-containing protein 1;Activator-recruited cofactor 92 kDa component;ARC/mediator transcriptional coactivator subunit;ARC/mediator transcriptional coactivator subunit ARC92;FLJ10193;MED25 protein;MED25_HUMAN;Mediator of RNA polymerase II transcription, subunit 25 homolog (S cerevisiae);Mediator of RNA polymerase II transcription, subunit 25 homolog (yeast);MGC70671;p78;prostate-derived protein 78 kDa;mediator of RNA polymerase II transcription, subunit 25 homolog;PTOV2;CMT2B2
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Avi
- Fc
- DDK
- Myc
- GST
Involved Pathway
MED25 involved in several pathways and played different roles in them. We selected most pathways MED25 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | ZNF324,NR0B1,ZNF41,NR2E3,ZNF334,HIPK1,KRBOX4,ZNF253,ZNF649,ZNF554 |
| Gene Expression | FAM98B,KHSRP,SF3B4,ZNF496,ZNF189,EHMT2,ZFP1,HNRNPA0L,NR4A2A,MED13A |
| PPARA activates gene expression | MED21,MED29,GLIPR1,SREBF2,MED7,CTGF,ANKRD1,GRHL1,MED6,MED20 |
| Developmental Biology | PLXNC1,RGMA,EFNA1,MED20,GPC1B,ITGB3A,SMAD3B,JAK1,ARPC1A,ANK2B |
| Metabolism | LYVE1,AK7,LMF1,FIG4,DIO2,PNP5B,SLC25A32A,KCNJ11,ABHD14B,ACY3.2 |
| Metabolism of lipids and lipoproteins | DHCR7,PLD6,APOF,CYP46A1,MED7,CYP2N13,FABP9,MED18,APOA4B.1,MED22 |
| Fatty acid, triacylglycerol, and ketone body metabolism | ECI1,ACOT9.1,MMAA,SREBF2,G0S2,MED21,CPT1B,Agmo,AGPAT6,ACOT7 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED19,MED10,MED16,MED23,MED7,MED21,MED31,CDK19,MED15,G0S2 |
Protein Function
MED25 has several biochemical functions, for example, protein binding,retinoic acid receptor binding,retinoid X receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED25 itself. We selected most functions MED25 had, and list some proteins which have the same functions with MED25. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | SIX2,APBB3,LMO4,NLK,PBX1,HYAL1,PPRC1,FOXO4,MAPK9,PER1 |
| retinoid X receptor binding | NRIP1,RARG,NSD1,HMGA1-RS1,PPARG,NR4A2,RARB,NCOR1,NR0B2,NCOA1 |
| retinoic acid receptor binding | ASXL1,PRAMEF1,PRAMEF6,PRAMEF2,AASS,RXRA,HMGA1,CTBP2,SNW1,ACTN4 |
| protein binding | ETS1,TRIM71,EHD1,NTS,MRPL1,SMAD5,PRMT5,TRIM43,TMED9,CIRH1A |
Interacting Protein
MED25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED25 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED25.
MED10;MED19;RXRA;MED26;MED9;RARA
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References
- Figueiredo, T; Melo, US; et al. Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family. JOURNAL OF MEDICAL GENETICS 52:123-127(2015).
- Caillaud, MC; Asai, S; et al. A Downy Mildew Effector Attenuates Salicylic Acid-Triggered Immunity in Arabidopsis by Interacting with the Host Mediator Complex. PLOS BIOLOGY 11:-(2013).
