MED24
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Official Full Name
mediator complex subunit 24 -
Overview
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. -
Synonyms
MED24;mediator complex subunit 24;cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa , CRSP4, THRAP4, thyroid hormone receptor associated protein 4;mediator of RNA polymerase II transcription subunit 24;CRSP100;DRIP100;KIAA0130
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rat
- Mouse
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- Myc&DDK
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
MED24 involved in several pathways and played different roles in them. We selected most pathways MED24 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | PRKCG,PIK3R3,ATP2A2,KAT2A,GATA4,AKT2,SRC,ATP1B4,SLC16A10,ATP1A1 |
Protein Function
MED24 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,histone acetyltransferase activity,ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED24 itself. We selected most functions MED24 had, and list some proteins which have the same functions with MED24. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | XPR1,SLC20A1,KLRB1F,ITGB1B.1,TNFRSF9,PAQR3B,CXCR3,LRP1,CD1D,PVR |
| histone acetyltransferase activity | NCOA2,HTATIP,NCOA1,KAT8,vnc,GTF3C4,KAT6A,EP300,CSRP2BP,TAF1L |
| RNA polymerase II transcription cofactor activity | MED19,MED30,MED20,MED4,MED10,MED9,MED21,CNOT2,MED18,MED11 |
| transcription cofactor activity | THRAP3,MED13,MXD1,PRKCBP1L,TFB2M,TRIP13,LDB1B,PSMC5,NFKBIZ,TAF13 |
| ligand-dependent nuclear receptor transcription coactivator activity | HMGA1-RS1,NCOA1,CCAR1,DCAF6,MED1,ZCCHC18,THRAP3,TADA3,PPARG,PRKCBB |
| ubiquitin protein ligase activity | PDZRN4,RNF144AA,RAG2,HERC2,FANCL,UBE3A,RNF111,MGRN1,SMURF2,RNF6 |
| protein binding | CCNY,FGFR3,DIAP1,PLCG1,NOP2,MAP6,CELF1,KCNA3,PEBP1,GOSR2 |
| thyroid hormone receptor binding | HMGN3,FUS,OASL,PRMT2,MED1,NSD1,ZNHIT3,NUP62,GAS2L1,THRAP3 |
| vitamin D receptor binding | RUNX2B,MED14,RXRA,MED1,MED4,MED30,SNW1,TAF11,THRAP3,MED17 |
Interacting Protein
MED24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED24 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED24.
MED10;CDK19;MED19;CDK8;MED9;Dlg4;MED14;CCNC;SMAD2;SMAD1;MED25;MED16
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References
- Chen, YR; Chen, CL; et al. Mitochondrial complex II in the post-ischemic heart - Oxidative injury and the role of protein S-glutathionylation. JOURNAL OF BIOLOGICAL CHEMISTRY 282:32640-32654(2007).
