MED21

  • Official Full Name

    mediator complex subunit 21

  • Overview

    It recognizes human SRB7, an essential component of SRB7/MED-containing cofactor complex (SMCC). This complex associates with the RNA polymerase II holoenzyme through SRB7 to enhance the gene-specific activation or repression induced by DNA-binding transcription factors.

  • Synonyms

    MED21;mediator complex subunit 21;SRB7;SURB7;mediator of RNA polymerase II transcription subunit 21;hSrb7;RNAPII complex component SRB7;RNA polymerase II complex component SRB7;RNA polymerase II holoenzyme component SRB7;SRB7 suppressor of RNA polymerase B homolog;SRB7 suppressor of RNA polymerase B homolog (yeast);SRB7 (suppressor of RNA polymerase B, yeast) homolog;OTTHUMP00000240653;OTTHUMP00000240654

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
MED21-807H Recombinant Human MED21, GST-tagged E.coli Human GST 1-144aa
MED21-3380H Recombinant Human MED21 protein, His-tagged E.coli Human His 1-144 aa
MED21-12595Z Recombinant Zebrafish MED21 Mammalian Cells Zebrafish His
MED21-2720R Recombinant Rhesus monkey MED21 Protein, His-tagged Mammalian Cells Rhesus macaque His
MED21-7607H Recombinant Human MED21, His-tagged E.coli Human Non 1-144aa
MED21-4388HCL Recombinant Human MED21 293 Cell Lysate HEK293 Human Non
MED21-1211H Recombinant Human MED21 protein, His-tagged E.coli Human His 159aa(including fusion tag)
MED21-2540R Recombinant Rhesus Macaque MED21 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MED21-2540R-B Recombinant Rhesus Macaque MED21 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Med21-360M Recombinant Mouse Med21 Protein, MYC/DDK-tagged HEK293 Mouse Myc&DDK

    Involved Pathway

    MED21 involved in several pathways and played different roles in them. We selected most pathways MED21 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism CYP3C4,ISCU,PYGMB,AFMID,DIO2,PNPLA8,CYP2C18,GSTK1,ACY3,AMDHD1
    Transcriptional regulation of white adipocyte differentiation CDK19,NR2F2,EBF1,MED29,MED22,MED9,MED18,EGR2,MED19
    Metabolism of lipids and lipoproteins PPM1LA,CPNE6,CSNK1G2,COQ6,EBP,SLC27A2A,CYP4F11,FAM213B,DPEP1,CETP
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) ANKRD1,CDK19,MED6,MED19,MED31,GRHL1,MED26,MED25,MED10,MED29
    PPARA activates gene expression MED18,MED26,APOA5,TIAM2,MED10,MED23,MED7,GRHL1,CDK19,MED8
    Developmental Biology CLTB,COL6A2,EFNA2A,CDK19,CARM1,MYL12B,SCN3B,MED22,ARPC5,CNTN6
    Fatty acid, triacylglycerol, and ketone body metabolism AGPAT1,ACOT9,CYP7A1,ACOT8,CTGF,ACOT11A,THEM5,SLC25A1A,DECR1,ACOT6

    Protein Function

    MED21 has several biochemical functions, for example, DNA-directed RNA polymerase activity,RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED21 itself. We selected most functions MED21 had, and list some proteins which have the same functions with MED21. You can find most of the proteins on our site.

    Function Related Protein
    transcription coactivator activity USP16,KAT2B,SMARCD1,CITED4,GTF2F1,EDF1,YAF2,MAK,TAF9,JUNBA
    protein binding GRIK5,DDOST,NCLN,UBE2V1,ZNF10,ALPL,EID3,MRPL10,PAM16,KIAA0319L
    DNA-directed RNA polymerase activity POLR2E,POLR3C,POLR2J,CD3EAP,PRIM2,POLR1C,POLR2D,POLR2EB,POLR3H,MED20
    RNA polymerase II transcription cofactor activity MED4,MED10,MED17,TDG,MED31,MED12,MED18,PPRC1,PPARGC1A,PPARGC1B
    ubiquitin protein ligase activity RFWD2,ANAPC11,TRIM3,WWP1,MARCH1,CBLL1,ZNRF1,RAD18,HACE1,FANCL

    Interacting Protein

    MED21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED21 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED21.

    MED10;MED9;MED19;MED26;SSC5D;MAGEB4

    Resources

    References

    • Tebbji, F; Chen, YL; et al. A Functional Portrait of Med7 and the Mediator Complex in Candida albicans. PLOS GENETICS 10:-(2014).
    • Shaikhibrahim, Z; Offermann, A; et al. MED12 overexpression is a frequent event in castration-resistant prostate cancer. ENDOCRINE-RELATED CANCER 21:663-675(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All MED21 Products

    Required fields are marked with *

    My Review for All MED21 Products

    Required fields are marked with *