MED21
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Official Full Name
mediator complex subunit 21 -
Overview
It recognizes human SRB7, an essential component of SRB7/MED-containing cofactor complex (SMCC). This complex associates with the RNA polymerase II holoenzyme through SRB7 to enhance the gene-specific activation or repression induced by DNA-binding transcription factors. -
Synonyms
MED21;mediator complex subunit 21;SRB7;SURB7;mediator of RNA polymerase II transcription subunit 21;hSrb7;RNAPII complex component SRB7;RNA polymerase II complex component SRB7;RNA polymerase II holoenzyme component SRB7;SRB7 suppressor of RNA polymerase B homolog;SRB7 suppressor of RNA polymerase B homolog (yeast);SRB7 (suppressor of RNA polymerase B, yeast) homolog;OTTHUMP00000240653;OTTHUMP00000240654
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MED21-807H | Recombinant Human MED21, GST-tagged | E.coli | Human | GST | 1-144aa | |
| MED21-3380H | Recombinant Human MED21 protein, His-tagged | E.coli | Human | His | 1-144 aa | |
| MED21-12595Z | Recombinant Zebrafish MED21 | Mammalian Cells | Zebrafish | His |
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| MED21-2720R | Recombinant Rhesus monkey MED21 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MED21-7607H | Recombinant Human MED21, His-tagged | E.coli | Human | Non | 1-144aa |
|
| MED21-4388HCL | Recombinant Human MED21 293 Cell Lysate | HEK293 | Human | Non |
|
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| MED21-1211H | Recombinant Human MED21 protein, His-tagged | E.coli | Human | His | 159aa(including fusion tag) |
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| MED21-2540R | Recombinant Rhesus Macaque MED21 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| MED21-2540R-B | Recombinant Rhesus Macaque MED21 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Med21-360M | Recombinant Mouse Med21 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
MED21 involved in several pathways and played different roles in them. We selected most pathways MED21 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid, triacylglycerol, and ketone body metabolism | ANKRD1,MED10,MTF1,TMEM195,DECR1,CYP7A1,HELZ2,Agmo,MED25,SLC25A1 |
| PPARA activates gene expression | MED16,CDK19,MED6,MED9,MED25,GRHL1,APOA5,MED20,MED29,TIAM2 |
| Developmental Biology | EBF1,DPYSL4,EFNA3B,TCF3B,EFNA1A,CSNK2B,GDF1,UNC5D,NR6A1,ACTR2 |
| Transcriptional regulation of white adipocyte differentiation | EGR2,EBF1,MED18,MED22,MED19,MED29,MED9,NR2F2,CDK19 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | G0S2,CDK19,CTGF,MED23,MED16,MED19,MED20,MED18,MED9,MED15 |
| Metabolism of lipids and lipoproteins | ARSI,SIN3B,ACOT9.2,ACOT13,PPARGC1B,CTGF,PLD6,COQ7,SLCO1B1,ACOT11A |
| Metabolism | LMF1,DPEP2,CSNK1G2,GPAT2,LRPPRC,CKB,B3GNT2,ACER1,DAO,SPTLC1 |
Protein Function
MED21 has several biochemical functions, for example, DNA-directed RNA polymerase activity,RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED21 itself. We selected most functions MED21 had, and list some proteins which have the same functions with MED21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED31,MED20,MED4,MED24,MED10,TDG,MED19A,MED7,MED8,MED30 |
| ubiquitin protein ligase activity | G2E3,TRIM3,CDC34A,RNF217,UBE2W,RNF111,RNF175,PRPF19,FBXO30,RNF126 |
| protein binding | TYRO3,KIAA1191,FEM1C,DPM3,MYOZ1,RIMS1,KLRC1,PAF1,RFX5,TEKT4 |
| transcription coactivator activity | CREBBP,ECD,SUB1B,TCF3,PARK7,YAP1,GRIP1,NR2C2,KAT2B,GATA4 |
| DNA-directed RNA polymerase activity | CD3EAP,POLR3C,PRIM2,POLR3B,POLR3G,POLR2EB,POLRMT,POLR2J,POLR2I,RPAP1 |
Interacting Protein
MED21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED21 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED21.
MED10;MED9;MED19;MED26;SSC5D;MAGEB4
Resources
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References
- Tebbji, F; Chen, YL; et al. A Functional Portrait of Med7 and the Mediator Complex in Candida albicans. PLOS GENETICS 10:-(2014).
- Shaikhibrahim, Z; Offermann, A; et al. MED12 overexpression is a frequent event in castration-resistant prostate cancer. ENDOCRINE-RELATED CANCER 21:663-675(2014).
