MED20
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Official Full Name
mediator complex subunit 20 -
Overview
MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with;DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al.,;2003 (PubMed 14576168)). -
Synonyms
MED20;mediator complex subunit 20;Trf (TATA binding protein related factor) proximal homolog (Drosophila) , TRFP;mediator of RNA polymerase II transcription subunit 20;DKFZp586D2223;PRO0213;TRF proximal protein homolog;TRFP;hTRFP;TRF-proximal protein homolog;Trf (TATA binding protein-related factor)-proximal homolog
Recombinant Proteins
- Zebrafish
- Chicken
- Rat
- Cynomolgus
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
MED20 involved in several pathways and played different roles in them. We selected most pathways MED20 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | ABHD14B,ISCU,FMODA,FABP11A,MED18,SGMS2,FABP11B,MED31,CYP46A1,SULT1ST6 |
| Developmental Biology | PITPNA,EPHA2A,SPRED2,MYL9,SPRED1,EFNA2,BOC,DCX,MED6,LGI2B |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED6,MED16,MED15,MED9,MTF1,MED19,CTGF,MED10,G0S2,MED7 |
| Generic Transcription Pathway | ZNF394,COX11,ZNF718,ZNF10,SESN3,ESR2A,ZNF596,CCNT2B,ZNF43,ZNF500 |
| Fatty acid, triacylglycerol, and ketone body metabolism | MTF1,AGPAT6,AGPAT1,ACOT9.2,ACOT12,DECR1,MED8,GRHL1,CPT1B,MED31 |
| PPARA activates gene expression | MED16,MED15,MED21,MED22,TIAM2,G0S2,MED31,MED23,MED19,GRHL1 |
| Metabolism of lipids and lipoproteins | PTPMT1,MED29,MED9,CPT2,SLC25A1A,AKR1C6,FABP12,CTGF,APOBB.1,PITPNB |
| Gene Expression | ADAT3,ZNF556,CTGF,DDOST,USP9,NFIB,FARS2,NRBP1,BAZ2A,FKBP6 |
Protein Function
MED20 has several biochemical functions, for example, DNA-directed RNA polymerase activity,RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED20 itself. We selected most functions MED20 had, and list some proteins which have the same functions with MED20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-directed RNA polymerase activity | POLR2EB,POLR3K,POLR3H,POLR3A,POLR2B,CCDC111,POLRMT,POLR2A,POLR3B,RPAP1 |
| ubiquitin protein ligase activity | UBR1,ANKIB1A,C12orf51,FANCF,HECTD3,MSL2A,CBLL1,RNF2,UBE2NB,HERC2 |
| protein binding | LANCL2,ENTPD1,C4orf19,CNNM3,SLC22A3,CLN6,TRPC5,ISG20L2,PSKH1,SMO |
| transcription coactivator activity | TBPL1,ESR2,NCOA2,KAT2B,CITED4,ARL2BP,SUB1B,WWTR1,JUN,NFKB2 |
| RNA polymerase II transcription cofactor activity | RBM14,MED22,MED1,MED13,NKX2,MED19B,PPARGC1A,CRSP7,MED14,PPRC1 |
Interacting Protein
MED20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED20 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED20.
MED10;MED29;MED19;MED18;CDK19
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