MED18
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Official Full Name
mediator complex subunit 18 -
Overview
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate;transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)). -
Synonyms
MED18;mediator complex subunit 18;mediator of RNA polymerase II transcription, subunit 18 homolog (S. cerevisiae);mediator of RNA polymerase II transcription subunit 18;FLJ20045;p28b;Human Mediator of RNA Polymerase II Transcription;hMED 18;hMED18;MED18_HUMAN;Mediator of RNA polymerase II transcription subunit 18 homolog;OTTHUMP00000003645;TRAP/mediator complex subunit p28b;mediator of RNA polymerase II transcription, subunit 18 homolog
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
MED18 involved in several pathways and played different roles in them. We selected most pathways MED18 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPARA activates gene expression | CDK19,MED20,APOA5,GRHL1,MED9,ANKRD1,TIAM2,MED25,CTGF,MED26 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED16,MED22,MTF1,GLIPR1,MED23,MED29,MED21,MED15,ANKRD1,MED25 |
| Fatty acid, triacylglycerol, and ketone body metabolism | AGPAT6,MED22,MED31,ACOT9.2,MED8,Agmo,AGPAT2,ACOT7,APOA5,MED21 |
| Metabolism of lipids and lipoproteins | AKR1C2,YAP1,ACOT11B,YY2,LBR,CDK19,ACAD11,FABP11A,CPNE7,PLIN2 |
| Metabolism | CKMB,SLC46A1,CYP2K19,SULT1C4,DGUOK,ARSJ,APOC2,ABCA1,NUBP1,NUDT4 |
| Transcriptional regulation of white adipocyte differentiation | EGR2,MED9,NR2F2,MED21,MED19,EBF1,CDK19,MED22,MED29 |
| Developmental Biology | PRDM14,LGI2,CDON,AP2S1,TDGF1,DPYSL5A,ADAM22,ANK2B,ITSN1,DUSP1 |
Protein Function
MED18 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED18 itself. We selected most functions MED18 had, and list some proteins which have the same functions with MED18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FHL2,TRIM35,SEPSECS,FAM46B,STRAP,HOXA10,TIA1,SULT1E1,RTF1,IL1RAPL1 |
| RNA polymerase II transcription cofactor activity | MDT-19,NKX2-5,MED13,MED24,CRSP7,PPARGC1B,MED21,MED19,MED26,CNOT2 |
Interacting Protein
MED18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED18 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED18.
MED10;MED29;Med20;MED19
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References
- Wu, CB; Sakorafas, P; et al. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. JOURNAL OF IMMUNOLOGY 170:5571-5577(2003).
