MED17
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Official Full Name
mediator complex subunit 17 -
Overview
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. -
Synonyms
MED17;mediator complex subunit 17;cofactor required for Sp1 transcriptional activation, subunit 6 (77kD) , cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa , CRSP6;mediator of RNA polymerase II transcription subunit 17;CRSP77;D
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
MED17 involved in several pathways and played different roles in them. We selected most pathways MED17 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | PIK3CB,MED13L,PIK3CA,THRB,NCOA3,PIK3R5,PRKACA,ATP1B1,PLCB4,PFKP |
Protein Function
MED17 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,ligand-dependent nuclear receptor transcription coactivator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED17 itself. We selected most functions MED17 had, and list some proteins which have the same functions with MED17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | HERC3,WWP1,PARK2,HERC6,RNF25,MSL2A,LRSAM1,UBE2G1,RNF115,MED31 |
| vitamin D receptor binding | RUNX2B,TAF11,MED1,MED4,TAF7,SNW1,THRAP3,MED24,MED14,RXRA |
| RNA polymerase II transcription cofactor activity | RBM14,MED24,MED9,PPARGC1B,MED19B,PPARGC1A,MED22,MED7,MED20,CNOT2 |
| transcription coactivator activity | TRIM32,WWTR1,PML,GTF2A2,KDM5A,ELF3,BRCA1,HSF2,MCIN,SUPT3H |
| protein binding | PAFAH1B3,BBC3,EFHC2,PDLIM4,ADPRH,INHA,AK8,RBM42,VTI1B,FBLIM1 |
| ligand-dependent nuclear receptor transcription coactivator activity | BUD31,ACTN4,PPARG,DCAF6,FGF2,NCOA1,TADA3,SS18,TSG101,HMGA1 |
| transcription cofactor activity | ZNF671,MAP3K7,NFE2L1,NFKBIZ,TAF13,MED1,LPXN,CALCOCO1,ZFP667,ZNF763 |
| receptor activity | TNFRSF25,NLGN3,CD1D,TNFRSF11A,KLRG1,JMJD6,DARC,PVRL3B,ATP6AP2,GRIK5 |
| thyroid hormone receptor binding | MED16,NR0B2,GTF2B,PRMT2,TAF7,TAF11,MED4,NCOR1,MED13,THRAP3 |
Interacting Protein
MED17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED17 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED17.
MED10;MED19;MED29;MED22;Med30
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