MED15
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Official Full Name
mediator complex subunit 15 -
Overview
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MED15;mediator complex subunit 15;PC2 (positive cofactor 2, multiprotein complex) glutamine/Q rich associated protein , PCQAP, TNRC7, trinucleotide repeat containing 7;mediator of RNA polymerase II transcription subunit 15;Arc105;CAG7A;TIG 1;Activator-recruited cofactor 105 kDa component;CTG repeat protein 7a;CTG7A;PC2 glutamine/Q-rich-associated protein;Positive cofactor 2 glutamine/Q-rich-associated protein;TIG-1;TIG1;TPA-inducible gene 1 protein;OTTHUMP00000198544;OTTHUMP00000198545;OTTHUMP00000198546;OTTHUMP00000198567;TPA inducible gene-1;TPA inducible protein;trinucleotide repeat containin;PCQAP;TNRC7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MED15-12302Z | Recombinant Zebrafish MED15 | Mammalian Cells | Zebrafish | His |
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| MED15-4392HCL | Recombinant Human MED15 293 Cell Lysate | HEK293 | Human | Non |
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| Med15-4013M | Recombinant Mouse Med15 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MED15-4478H | Recombinant Human MED15 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MED15-4823H | Recombinant Human MED15 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MED15-6202HF | Recombinant Full Length Human MED15 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 674 amino acids |
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Involved Pathway
MED15 involved in several pathways and played different roles in them. We selected most pathways MED15 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid, triacylglycerol, and ketone body metabolism | MED26,MED9,MED25,MED23,ACSF3,SLC25A20,DGAT1B,G0S2,ELOVL1A,MED29 |
| Metabolism of lipids and lipoproteins | SLC25A1A,ARSJ,CERS4A,VAPB,ACSF2,SPTLC1,DPEP1,G0S2,APOA5,FIG4 |
| PPARA activates gene expression | MED19,MED8,CDK19,ANKRD1,MED22,TIAM2,MTF1,MED25,MED6,G0S2 |
| Generic Transcription Pathway | ZNF426,MED16,RORAA,NR2E3,ZNF561,ZNF383,ZNF460,ZNF433,ZNF764,ZNF100 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED23,MED10,GLIPR1,MED9,CTGF,PLIN2,MED6,MED26,MED16,ANKRD1 |
| Developmental Biology | KCNQ3,SMAD3B,GDNF,ACTR3,KDR,KCNQ2,EFNA3,MED21,EFNA5,PAQR3B |
| Gene Expression | PSTPIP2,C2orf49,SNAPC4,MTA2,C7orf59,SNAPC5,ZNF544,CSTF3,HNRNPH1L,TYW3 |
| Metabolism | ADHFE1,OAZ2,UPP2,ISCUB,LMF2,CHKA,AQP1A.1,PLIN2,NUDT3B,NDUFAF7 |
Protein Function
MED15 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED15 itself. We selected most functions MED15 had, and list some proteins which have the same functions with MED15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FOXL2,TRAPPC5,SGSM3,RND2,FBXW2,ARFRP1,LUZP4,ALKBH6,HER5,UBE2C |
| RNA polymerase II transcription cofactor activity | MED19B,MED26,MED24,MDT-19,MED21,MED17,MED7,TP53BP1,RBM14,MED9 |
Interacting Protein
MED15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED15 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED15.
CDK8;SREBF1;MED10;CDK19;MED19;MED26
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