MED13L
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Official Full Name
mediator complex subunit 13-like -
Overview
The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA). -
Synonyms
MED13L;mediator complex subunit 13-like;THRAP2, thyroid hormone receptor associated protein 2;mediator of RNA polymerase II transcription subunit 13-like;KIAA1025;TRAP240L;MD13L_HUMAN;Mediator complex subunit 13 like;THRAP2;Thyroid hormone receptor-associated protein 2;Thyroid hormone receptor-associated protein complex 240 kDa component-like;PROSIT240
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MED13L-2718R | Recombinant Rhesus monkey MED13L Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MED13L-906H | Recombinant Human MED13L | Mammalian Cells | Human | His |
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| MED13L-2538R | Recombinant Rhesus Macaque MED13L Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| MED13L-2538R-B | Recombinant Rhesus Macaque MED13L Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| MED13L-3450H | Recombinant Human MED13L Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| MED13L-3450H-B | Recombinant Human MED13L Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
MED13L involved in several pathways and played different roles in them. We selected most pathways MED13L participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED13L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | ATP1A4,MAP2K2,RXRA,FXYD2,MAPK1,PLCB2,ACTB,GATA4,PLN,NCOA3 |
Protein Function
MED13L has several biochemical functions, for example, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED13L itself. We selected most functions MED13L had, and list some proteins which have the same functions with MED13L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED19A,CNOT2,MED17,RBM14,THRAP3,NKX2-5,MED20,MED15,MED13B,MED13A |
Interacting Protein
MED13L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED13L here. Most of them are supplied by our site. Hope this information will be useful for your research of MED13L.
CDK19;MED19;MED26;CDK8;MED10;MED9;SYNCRIP;1C;HIF1A;Med22;Med28
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References
- Lu, XF; Wang, LY; et al. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. HUMAN MOLECULAR GENETICS 24:865-874(2015).
- van Haelst, MM; Monroe, GR; et al. Further confirmation of the MED13L haploinsufficiency syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:135-138(2015).
