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MECOM

Official Full Name

MDS1 and EVI1 complex locus
Overview

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
Synonyms

EVI1; MDS1; PRDM3; MGC97004; MDS1-EVI1; MGC163392; AML1-EVI-1; MDS1 and EVI1 complex locus protein EVI1; oncogene EVI1; OTTHUMP00000213163; OTTHUMP00000213164; OTTHUMP00000213165; OTTHUMP00000213187; OTTHUMP00000213191; OTTHUMP00000213192; zinc finger protein Evi1; AML1-EVI-1 fusion protein; MDS1 and EVI1 complex locus protein MDS1; myelodysplasia syndrome-associated protein 1; ecotropic virus integration site 1 protein homolog; MDS1 and EVI1 complex locus; MECOM;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MECOM-28333TH	Recombinant Human MECOM	Wheat Germ	Non	99 amino acids	Inquiry
Human	MECOM-4396HCL	Recombinant Human MECOM 293 Cell Lysate	HEK293	Non		Inquiry
Human	MECOM-4490H	Recombinant Human MECOM Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MECOM-6118HF	Recombinant Full Length Human MECOM Protein, GST-tagged	In Vitro Cell Free System	GST	169 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MECOM involved in several pathways and played different roles in them. We selected most pathways MECOM participated on our site, such as MAPK signaling pathway, Pathways in cancer, Chronic myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with MECOM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	MAPK13;MAPKAPK5;MAPKAPK2;PPM1A;CACNA1G;ATF4;PLA2G4A;FGF20B;ARRB2B
Pathways in cancer	GNAI2;Kitl;ERBB2;BRAF;PTCH2;RALBP1;Shh;VEGFC;F2RL3
Chronic myeloid leukemia	CDK6;RB1;CTBP2;MECOM;RUNX1;SHC2;MAPK3;AKT1;CTBP1

MECOM has several biochemical functions, for example, DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MECOM itself. We selected most functions MECOM had, and list some proteins which have the same functions with MECOM. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	DNAJC1;ZFP451;ZFP574;RFX8;ZNF669;ZSCAN10;ZNF333;PURG;IRF1B
metal ion binding	CNOT7;RPS27A;ADNP2;ATP2B1;DGCR8;PPP4CB;VAV2;REV1;PVALB5
protein binding	APPBP2;FRMD6;LGALS13;WBSCR27;MET;KRT25;SBNO2;SLC6A3;GINS2
protein homodimerization activity	XDH;USF2;NPPC;SNX2;SLC51A;KLRB1B;B4GALT1;CD200;GRPEL2
NOT protein homodimerization activity	NUDT16L1;EXT2;MSH3;MSH6;DDIT3;MYO9B;KCNA3;MECOM;MLXIPL
transcription factor activity, sequence-specific DNA binding	ZNF45;ZNF624;CSRNP1;NFATC1;HNF1BB;MECP2;RORAA;ZFP518A;PGBD1

MECOM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MECOM here. Most of them are supplied by our site. Hope this information will be useful for your research of MECOM.

Ctbp2; UXT; SIRT1

Research Area

Hematopoietic Stem Cell Markers

Jancuskova, T; Plachy, R; et al. Molecular characterization of the rare translocation t(3;10)(q26;q21) in an acute myeloid leukemia patient. MOLECULAR CYTOGENETICS 7:-(2014).

Bard-Chapeau, EA; Szumska, D; et al. Mice Carrying a Hypomorphic Evi1 Allele Are Embryonic Viable but Exhibit Severe Congenital Heart Defects. PLOS ONE 9:-(2014).