MECOM
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Official Full Name
MDS1 and EVI1 complex locus -
Overview
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. -
Synonyms
EVI1;MDS1;PRDM3;MGC97004;MDS1-EVI1;MGC163392;AML1-EVI-1;MDS1 and EVI1 complex locus protein EVI1;oncogene EVI1;OTTHUMP00000213163;OTTHUMP00000213164;OTTHUMP00000213165;OTTHUMP00000213187;OTTHUMP00000213191;OTTHUMP00000213192;zinc finger protein Evi1;AML1-EVI-1 fusion protein;MDS1 and EVI1 complex locus protein MDS1;myelodysplasia syndrome-associated protein 1;ecotropic virus integration site 1 protein homolog;MDS1 and EVI1 complex locus;MECOM
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MECOM-28333TH | Recombinant Human MECOM | Wheat Germ | Human | Non | 99 amino acids |
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| MECOM-4396HCL | Recombinant Human MECOM 293 Cell Lysate | HEK293 | Human | Non |
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| MECOM-4490H | Recombinant Human MECOM Protein, GST-tagged | Wheat Germ | Human | GST |
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| MECOM-6118HF | Recombinant Full Length Human MECOM Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 169 amino acids |
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Involved Pathway
MECOM involved in several pathways and played different roles in them. We selected most pathways MECOM participated on our site, such as MAPK signaling pathway,Pathways in cancer,Chronic myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with MECOM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | PIK3R5,CRK,CBLB,CTBP2,STAT5B,CBL,IKBKB,IKBKG,RB1,PTPN11 |
| Pathways in cancer | WNT7A,GNG13,CXCR4,MTOR,PML,PLCG1,LAMB3,FGF18,WNT11,IL-8 |
| MAPK signaling pathway | PRKACAA,MEF2C,PRKACBB,HSPA1B,MAP3K6,PPM1NA,MAPK14B,MAPT,MKNK1,MAP2K4 |
Protein Function
MECOM has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MECOM itself. We selected most functions MECOM had, and list some proteins which have the same functions with MECOM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | TRP53,ZNF707,HIST1H2AF,NKX2-3,EPAS1,HIST1H2AB,RCAN1,YEATS4,HER8A,ZSCAN18 |
| metal ion binding | KLK1B4,SMYD2B,CYB5A,OAS2,GTSF1,LNX2A,ZFP473,SGSH,RHO,PPM1DA |
| transcription factor activity, sequence-specific DNA binding | CRX,HNF4G,GTF2H3,RFXAP,PDX1,FBXW7,DMRTA1,TFCP2L1,MNX2A,ZSCAN4F |
| NOT protein homodimerization activity | DDIT3,MLXIPL,MYO9B,MSH3,MSH6,KCNA3,EXT2,NUDT16L1 |
| protein homodimerization activity | DNTTIP1,PRKG2,DPYD,SMAD4,PYCARD,LCN2,S100A13,TYR,PTPRE,PCYT1A |
| protein binding | CRYBB1,TLX2,GPI1,KRTAP9-4,RAB2A,STK25,THAP11,BDKRB2,SWSAP1,HELZ |
Interacting Protein
MECOM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MECOM here. Most of them are supplied by our site. Hope this information will be useful for your research of MECOM.
Ctbp2;UXT;SIRT1
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References
- Jancuskova, T; Plachy, R; et al. Molecular characterization of the rare translocation t(3;10)(q26;q21) in an acute myeloid leukemia patient. MOLECULAR CYTOGENETICS 7:-(2014).
- Bard-Chapeau, EA; Szumska, D; et al. Mice Carrying a Hypomorphic Evi1 Allele Are Embryonic Viable but Exhibit Severe Congenital Heart Defects. PLOS ONE 9:-(2014).
