ME1
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Official Full Name
malic enzyme 1, NADP(+)-dependent, cytosolic -
Overview
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. -
Synonyms
ME1;malic enzyme 1, NADP(+)-dependent, cytosolic;NADP-dependent malic enzyme;NADP-ME;malate dehydrogenase;malic enzyme 1, soluble;Malic enzyme, cytoplasmic;pyruvic-malic carboxylase;MES;HUMNDME
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- DDK
- Myc
- Non
- Avi
- Fc
- Flag
Involved Pathway
ME1 involved in several pathways and played different roles in them. We selected most pathways ME1 participated on our site, such as Pyruvate metabolism,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ME1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | PRPS2,IDH3G,SDHB,GPI1,EHHADH,GPT2L,ACSS2,PKLR,SDHDB,GLUD2 |
| Metabolic pathways | LAP3,GALNT12,CNDP1,EHHADH,ACACA,ATP5I,HADHAB,COQ7,OGDH,ENPP7 |
| Pyruvate metabolism | LDHBA,ACYP2,PKMA,LDHAL6A,ALDH2.2,MDH1AA,DLDH,PKM,PCXB,ALDH3A2 |
| PPAR signaling pathway | FABP1A,PDPK1,PPARAB,SCP2,AQP7,ACSL3A,ACSL4B,UBC,ILK,SLC27A4 |
Protein Function
ME1 has several biochemical functions, for example, ADP binding,NAD binding,NADP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ME1 itself. We selected most functions ME1 had, and list some proteins which have the same functions with ME1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP binding | ADCK3,MYH10,GCLC,PKM,ATP1A1,GLUD2,PRKAG1,CHORDC1,GLUD1,CYB5R3 |
| malic enzyme activity | ME3,ME2,MDH1 |
| NAD binding | CYB5R3,PHGDH,BDH2,CTBP1,GPD1C,HSD11B2,HIBADHB,IDH2,IDH3G,HADHA |
| malate dehydrogenase (decarboxylating) (NADP+) activity | ME3 |
| oxaloacetate decarboxylase activity | ME3,ME2,FAHD1 |
| malate dehydrogenase (decarboxylating) (NAD+) activity | ME3,ME2 |
| manganese ion binding | HMGCL,ABL2,PPM1A,GYLTL1B,PPM1NB,NPEPL1,NUDT16,XPNPEP1,IMPA1,PPM1M |
| NADP binding | IDH1,MTRR,NNT,FMO3,PGD,NOS2,DPYD,NOX5,GAPDH,NOS3 |
| electron carrier activity | TXNRD1,PTGES2,ASPH,CYP19A1,P4HA2,NQO2,UGDH,DHRS3,ACOXL,IVD |
Interacting Protein
ME1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ME1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ME1.
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References
- Seidu, MA; Adams, AR; et al. Immunoreactivity of some epitopes in longtime inappropriately stored paraffin-embedded tissues. JOURNAL OF HISTOTECHNOLOGY 36:59-64(2013).
- Chen, LY; Fischer, R; et al. Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27. ARTHRITIS & RHEUMATOLOGY 66:284-294(2014).
