MDC1
-
Official Full Name
mediator of DNA-damage checkpoint 1 -
Overview
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008] -
Synonyms
MDC1;mediator of DNA-damage checkpoint 1;NFBD1;mediator of DNA damage checkpoint protein 1;nuclear factor with BRCT domains 1;mediator of DNA damage checkpoint 1;homologue to Drosophila photoreceptor protein calphotin
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mammalian Cells
- Yeast
- E.coli
- HEK293
- His
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MDC1-2709R | Recombinant Rhesus monkey MDC1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
|
|
| MDC1-3626R | Recombinant Rat MDC1 Protein | Mammalian Cells | Rat | His |
|
|
| MDC1-2039H | Recombinant Human MDC1 Protein (1892-2082 aa), His-tagged | Yeast | Human | His | 1892-2082 aa |
|
| MDC1-2343H | Recombinant Human MDC1 Protein (1892-2082 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1892-2082 aa |
|
| MDC1-2529R | Recombinant Rhesus Macaque MDC1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
|
| MDC1-2529R-B | Recombinant Rhesus Macaque MDC1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
||
| MDC1-3282R | Recombinant Rat MDC1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| MDC1-3282R-B | Recombinant Rat MDC1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
Involved Pathway
MDC1 involved in several pathways and played different roles in them. We selected most pathways MDC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MDC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MDC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MDC1 itself. We selected most functions MDC1 had, and list some proteins which have the same functions with MDC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
MDC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDC1.
Resources
Related Services
Related Products
References
- Chowdhury, F; Johnson, PW; et al. Ex Vivo Assays of Dendritic Cell Activation and Cytokine Profiles as Predictors of In Vivo Effects in an Anti-Human CD40 Monoclonal Antibody ChiLob 7/4 Phase I Trial. CANCER IMMUNOLOGY RESEARCH 2:229-240(2014).
- Nikoueinejad, H; Amirzargar, A; et al. Dynamic Changes of Regulatory T Cell and Dendritic Cell Subsets in Stable Kidney Transplant Patients A Prospective Analysis. IRANIAN JOURNAL OF KIDNEY DISEASES 8:130-138(2014).
