MCPH1
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Official Full Name
MCPH1 microcephalin 1 -
Overview
MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation -
Synonyms
MCPH1;microcephalin 1;microcephaly, primary autosomal recessive 1;microcephalin;BRCT repeat inhibitor of TERT expression 1;BRIT1;FLJ12847;BRCT-repeat inhibitor of TERT expression 1;MCT
Recombinant Proteins
- Chicken
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MCPH1-3750C | Recombinant Chicken MCPH1 | Mammalian Cells | Chicken | His |
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| MCPH1-9647M | Recombinant Mouse MCPH1 Protein | Mammalian Cells | Mouse | His |
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| MCPH1-4412HCL | Recombinant Human MCPH1 293 Cell Lysate | HEK293 | Human | Non |
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| MCPH1-4512H | Recombinant Human MCPH1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MCPH1-5420M | Recombinant Mouse MCPH1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MCPH1-5420M-B | Recombinant Mouse MCPH1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MCPH1-6087HF | Recombinant Full Length Human MCPH1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 610 amino acids |
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Involved Pathway
MCPH1 involved in several pathways and played different roles in them. We selected most pathways MCPH1 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Condensation of Prophase Chromosomes, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCPH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitotic Prophase | NEK6,CTDNEP1A,ARPP19B,SMC2,ARPP19A,CTDNEP1,NCAPH2,PHF8,MASTL,NCAPD3 |
| Cell Cycle, Mitotic | NIPBLA,ARPP19,CENPI,CDKN2A,E2F2,NCAPH,CEP152,NIPBL,NEDD1,MAU2 |
| Cell cycle | ZBTB17,CCNB2,CCNA1,CDC25A,BARD1,FZR1,HAUS2,ODF2B,GORASP1,CEP78 |
| M Phase | ZWINT,GORASP1,CTDNEP1A,NUF2,SMC2,ENSAB,RCC2,SGOL1,CDCA8,PDS5B |
| Condensation of Prophase Chromosomes | NCAPH2,SETA,H3F3D,H3F3B.1,SMC4,NCAPD3,PHF8,SET,NCAPG2,SMC2 |
Protein Function
MCPH1 has several biochemical functions, for example, identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCPH1 itself. We selected most functions MCPH1 had, and list some proteins which have the same functions with MCPH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | RASSF3,S100A1,MLL1,MVK,USP4,SH3GL1,VIL1,CCL3,DAAM1,OAT |
| protein binding | FUBP3,CCDC6,PRPF6,EGF,RAB6A,CST5,MMP2,ZNF614,GAN,SETX |
Interacting Protein
MCPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCPH1.
E2F1;E2F2;KDM1A;TADA2A;ABCC2;PHF11;RNF8
Resources
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References
- Zhang, B; Wang, E; et al. Phosphorylation of the BRCA1C Terminus (BRCT) Repeat Inhibitor of hTERT (BRIT1) Protein Coordinates TopBP1 Protein Recruitment and Amplifies Ataxia Telangiectasia-mutated and Rad3-related (ATR) Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 289:34284-34295(2014).
- Ishitobi, Y; Inoue, A; et al. Association of Microcephalin 1, Syntrophin-Beta 1, and Other Genes with Automatic Thoughts in the Japanese Population. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 165:492-501(2014).
