MCM8
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Official Full Name
minichromosome maintenance complex component 8 -
Overview
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are;essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM;proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of;replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central;domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and;7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively;spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
MCM8;minichromosome maintenance complex component 8;C20orf154, chromosome 20 open reading frame 154;DNA replication licensing factor MCM8;dJ967N21.5;MGC4816;MGC12866;MGC119522;MGC119523;REC;REC homolog (Drosophila);REC homolog;minichromosome
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
Involved Pathway
MCM8 involved in several pathways and played different roles in them. We selected most pathways MCM8 participated on our site, such as Activation of ATR in response to replication stress,Activation of the pre-replicative complex,Assembly of the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CDT1 association with the CDC6:ORC:origin complex | CDT1,GMNN |
| Activation of the pre-replicative complex | CDT1,DBF4,CDK2,MCM10 |
| Cell cycle | CDC14AA,CENPH,TFDP1A,NUP50,CDC27,GSK3AA,DIDO1,CEP76,ANAPC2,NCAPH |
| Cell Cycle, Mitotic | PLK4,CEP152,CKS1B,CDKN2C,OFD1,PCM1,NUDC,NUP35,SKA2,ACTR1A |
| Assembly of the pre-replicative complex | E2F2,GMNN,E2F1,CDT1,E2F3 |
| Activation of ATR in response to replication stress | MCM10,DBF4,CHEK1,RAD1,HUS1,RAD9B,RAD9,CDK2,CLSPN,RAD17 |
| Cell Cycle Checkpoints | YWHAQ,MCM10,BABAM1,CDK5RAP2,BRE,CLSPN,RAD9,CDKN1B,BARD1,CHEK1 |
| CDC6 association with the ORC:origin complex | E2F2,E2F3 |
Protein Function
MCM8 has several biochemical functions, for example, ATP binding,DNA binding,helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM8 itself. We selected most functions MCM8 had, and list some proteins which have the same functions with MCM8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF766,SAP30L,HIST1H2AD,SMARCC1B,ZBTB8B,ZNF547,NR2F1A,IGHMBP2,TTC5,GM239 |
| protein binding | SORBS3,ZNF177,LEMD3,MAP2K7,Ccl27a,CDC23,PYGL,PSTPIP1,BLOC1S5,RIPK1 |
| helicase activity | DDX19,UPF1,IFIH1,DDX6,CHD9,DHX36,MCM9,ZRANB3,RAD54L,NAV2 |
| ATP binding | DYNC2H1,NPR1A,FGFR1,AGAP2,STRC,PLK2B,CDK5,GSK3B,CASKA,MAGI3 |
Interacting Protein
MCM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM8.
MCMBP
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