MCM10

  • Official Full Name

    minichromosome maintenance complex component 10

  • Overview

    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

  • Synonyms

    MCM10;minichromosome maintenance complex component 10;MCM10 minichromosome maintenance deficient 10 (S. cerevisiae);protein MCM10 homolog;CNA43;DNA43;PRO2249;FLJ31133;HsMCM10;MCM10 minichromosome maintenance deficient 10;MCM10_HUMAN;Minichromosome maintenance protein 10 isoform 1;homolog of yeast MCM10
Cat.# Product name Source (Host) Species Tag Protein Length Price
MCM10-3060Z Recombinant Zebrafish MCM10 Mammalian Cells Zebrafish His
MCM10-9633M Recombinant Mouse MCM10 Protein Mammalian Cells Mouse His
MCM10-4421HCL Recombinant Human MCM10 293 Cell Lysate HEK293 Human Non
MCM10-5409M Recombinant Mouse MCM10 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
MCM10-5409M-B Recombinant Mouse MCM10 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MCM10 involved in several pathways and played different roles in them. We selected most pathways MCM10 participated on our site, such as Activation of ATR in response to replication stress,Activation of the pre-replicative complex,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle CHEK1,TGFB1,CENPW,PRKDC,ESCO2,NEK2,NCAPH2,TMEM188,ORC6,ANKLE2
    Cell Cycle Checkpoints HUS1,YWHAQ,HIST3H2BB,BABAM1,RAD9,DBF4,HIST4H4,CDK2,BRCC3,CDKN1B
    DNA Replication Pre-Initiation GMNN,DBF4,CDT1
    DNA Replication PCNA,GINS1,MCM7,POLE2,RPA1,MCM2,RFC3,MCM5,PRIM1,PRIM2
    Cell Cycle, Mitotic TUBB4B,ARPP19B,MCM8,MAPRE1A,CENPJ,CEP70,STAG2,PDS5B,SETB,MASTL
    Activation of ATR in response to replication stress RAD1,DBF4,CLSPN,RAD9B,RAD17,RAD9,CDK2,HUS1,RAD9A,CHEK1
    Activation of the pre-replicative complex MCM8,CDT1,CDK2,DBF4

    Protein Function

    MCM10 has several biochemical functions, for example, DNA replication origin binding,double-stranded DNA binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM10 itself. We selected most functions MCM10 had, and list some proteins which have the same functions with MCM10. You can find most of the proteins on our site.

    Function Related Protein
    DNA replication origin binding ORC2L,CDC45,MCM5,MCM2,ORC3L,HSPD1,ORC4L,ORC4
    identical protein binding DAAM1,HSD17B10,ANXA4,ENTPD2,NUDT16,CORO1B,E2F7,DRD4,ZDHHC17,DACT3
    metal ion binding GDPD1,ZFP57,C1GALT1B,MOB4,PPM1DA,BIRC5,HELZ,TENC1,KCNIP3A,TNNI3K
    protein binding ARNT,RPA2,INTS9,THAP3,CCL3,RAD1,CEP152,NPY1R,FAM69A,MID2
    single-stranded DNA binding SUB1,RAD51L3,CDC45,ERCC1,LUZP4,NEIL3,TREX1,RAD51,SSBP3A,ALYREF
    double-stranded DNA binding RAD51L1,XRCC5,ERCC5,MTERFD3,TP73,XRCC2,IFI16,TRP63,HLF,MEN1

    Interacting Protein

    MCM10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM10.

    ORC2;MCM6;TRIM37;CDC7;ORC4;CDC45;CCND1;MCM3;CCND3;MCM7;CDKN1A;CDKN2A

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