MCEE
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Official Full Name
methylmalonyl CoA epimerase -
Overview
The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. -
Synonyms
MCEE;methylmalonyl CoA epimerase;methylmalonyl-CoA epimerase, mitochondrial;GLOD2;glyoxalase domain containing 2;mitochondrial;DL methylmalonyl CoA racemase;DL-methylmalonyl-CoA racemase;EC 5.1.99.1;MCEE_HUMAN;METHYLMALONYL CoA RACEMASE;Methylmalonyl-CoA epimerase
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Mouse
- Rat
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MCEE-2906Z | Recombinant Zebrafish MCEE | Mammalian Cells | Zebrafish | His |
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| MCEE-29452TH | Recombinant Human MCEE, His-tagged | E.coli | Human | His | 140 amino acids |
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| MCEE-5550C | Recombinant Chicken MCEE | Mammalian Cells | Chicken | His |
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| MCEE-5551C | Recombinant Chicken MCEE | Mammalian Cells | Chicken | His |
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| MCEE-801H | Recombinant Human Methylmalonyl CoA Epimerase, His-tagged | E.coli | Human | His |
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| MCEE-9626M | Recombinant Mouse MCEE Protein | Mammalian Cells | Mouse | His |
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| MCEE-4426HCL | Recombinant Human MCEE 293 Cell Lysate | HEK293 | Human | Non |
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| Mcee-1734M | Recombinant Mouse Mcee protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gln39~Ala178 (Accession # Q9D1I5) |
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| Mcee-1735R | Recombinant Rat Mcee protein, His & T7-tagged | E.coli | Rat | His&T7 | Gln39~Ala178 (Accession # D4A197) |
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| MCEE-5210H | Recombinant Human MCEE Protein (Gln37-Ala176), C-His tagged | Mammalian Cells | Human | His | Gln37-Ala176 |
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| MCEE-5211H | Recombinant Human MCEE Protein (Gln37-Ala176), N-His tagged | E.coli | Human | His | Gln37-Ala176 |
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| MCEE-5406M | Recombinant Mouse MCEE Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MCEE-5406M-B | Recombinant Mouse MCEE Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MCEE involved in several pathways and played different roles in them. We selected most pathways MCEE participated on our site, such as Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCEE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Valine, leucine and isoleucine degradation | AOX2P,ACAA1,IVD,AOX4,AOX3L1,ALDH6A1,HADH,HIBADHB,MCCC1,AOX3 |
| Glyoxylate and dicarboxylate metabolism | GRHPRA,SHMT1,ACAT2,HAO2,MDH2,CAT,DLDH,HOGA1,GRHPR,GLULB |
| Metabolic pathways | ATP6V0A1A,TPH2,ALDH7A1,ATP6V1C1,NDUFB7,IMPAD1,ATP6V1B1,CYP3A41B,COQ7,COX7B |
| Carbon metabolism | DLDH,HK3,AGXTA,PSAT1,ME2,PFKL,HKDC1,pykF,ACADM,G6PD |
| Propanoate metabolism | ACACA,HADHA,PCCA,ACACB,BCKDHA,ACAT1,SUCLA2,ACADM,ECHDC1,ACSS3 |
Protein Function
MCEE has several biochemical functions, for example, metal ion binding,methylmalonyl-CoA epimerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCEE itself. We selected most functions MCEE had, and list some proteins which have the same functions with MCEE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EDAR,CYFIP1,EHD1,ATRX,TBX22,RAN,SERPINB9,SNRPB,FES,KEAP1 |
| metal ion binding | TRIM26,NRXN2B,ZFP879,OVCH2,PDE7A,SALL3,MOBKL2B,ZNF45,ZBTB14,E4F1 |
Interacting Protein
MCEE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCEE here. Most of them are supplied by our site. Hope this information will be useful for your research of MCEE.
AGTRAP;CMTM5
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References
- Guan, NZ; Shin, HD; et al. Understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the level of proteomics. SCIENTIFIC REPORTS 4:-(2014).
- Depuydt, G; Xie, F; et al. LC-MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism. JOURNAL OF PROTEOME RESEARCH 13:1938-1956(2014).
