MCCC2
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Official Full Name
methylcrotonoyl-CoA carboxylase 2 (beta) -
Overview
This gene encodes the small subunit of3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, anautosomal recessive disorder of leucine catabolism. -
Synonyms
MCCC2;methylcrotonoyl-CoA carboxylase 2 (beta);methylcrotonoyl Coenzyme A carboxylase 2 (beta);methylcrotonoyl-CoA carboxylase beta chain, mitochondrial;MCCB;biotin carboxylase;MCCase subunit beta;3-methylcrotonyl-CoA carboxylase 2;methylcrotonoyl
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MCCC2-12180Z | Recombinant Zebrafish MCCC2 | Mammalian Cells | Zebrafish | His |
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| MCCC2-3615R | Recombinant Rat MCCC2 Protein | Mammalian Cells | Rat | His |
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| MCCC2-8174H | Recombinant Human MCCC2 protein, His & T7-tagged | E.coli | Human | His&T7 | Arg337~Met563 |
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| Mccc2-8175M | Recombinant Mouse Mccc2 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ser380~Met563 |
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| MCCC2-4428HCL | Recombinant Human MCCC2 293 Cell Lysate | HEK293 | Human | Non |
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| MCCC2-189H | Recombinant Human MCCC2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MCCC2-3271R | Recombinant Rat MCCC2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| MCCC2-3271R-B | Recombinant Rat MCCC2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Mccc2-3991M | Recombinant Mouse Mccc2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
MCCC2 involved in several pathways and played different roles in them. We selected most pathways MCCC2 participated on our site, such as Valine, leucine and isoleucine degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Valine, leucine and isoleucine degradation | OXCT2B,ALDH1B1,HIBADH,BCKDHA,HADH,OXCT1,MUT,MCCC1,ALDH2,ACAT2 |
| Metabolic pathways | ACADL,GLUL,GCH2,KMO,NAPRT,HADHAA,B3GAT3,NT5C3A,ALDH1A2,CYP27A1 |
Protein Function
MCCC2 has several biochemical functions, for example, ATP binding,methylcrotonoyl-CoA carboxylase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCCC2 itself. We selected most functions MCCC2 had, and list some proteins which have the same functions with MCCC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylcrotonoyl-CoA carboxylase activity | MCCC1 |
| protein binding | MAGI1,WTAP,NUP85,SIRT1,SYT4,GOPC,ADAM22,PSMD6,RFC5,WDFY2 |
| ATP binding | ATP7B,DYRK1B,UBE2D3,CHEK2,PIP4K2A,CSK,FIGNL1,OXSR1A,PTK6,ATP13A1 |
Interacting Protein
MCCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCCC2.
INPPL1;US11;IFIT1;b14_vaccw;EPS15;GABARAPL2;k7_vaccw;STK4;ICT1;UBASH3B;HDAC11;ECSIT;MAP1LC3A;SIRT4
Resources
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References
- Hwu, WL; Suzuki, Y; et al. Late-onset holocarboxylase synthetase deficiency with homologous R508W mutation. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 99:174-177(2000).
