MCC
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Official Full Name
mutated in colorectal cancers -
Overview
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MCC;mutated in colorectal cancers;colorectal mutant cancer protein;DKFZp762O1615;FLJ38893;FLJ46755;MCC 1;MCC1;Protein MCC;OTTHUMP00000159017;OTTHUMP00000222860;OTTHUMP00000223206
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MCC-774H | Recombinant Human MCC, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| MCC-3276H | Recombinant Human MCC protein, His-tagged | E.coli | Human | His | 480-829 aa | |
| MCC-3391H | Recombinant Human MCC protein, His-tagged | E.coli | Human | His | 480-635 aa | |
| MCC-4430HCL | Recombinant Human MCC 293 Cell Lysate | HEK293 | Human | Non |
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| Mcc-3990M | Recombinant Mouse Mcc Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
MCC involved in several pathways and played different roles in them. We selected most pathways MCC participated on our site, such as TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF-alpha/NF-kB Signaling Pathway | TNIP1,TANK,CAPN3,RNF25,RNF216,FAF1,TRAIP,SMARCB1,PFDN2,SMARCE1 |
Protein Function
MCC has several biochemical functions, for example, protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCC itself. We selected most functions MCC had, and list some proteins which have the same functions with MCC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | ERBB3B,CLEC4E,ANXA2R,NOTCH1,TNFRSF6B,CALCR,ABP1,VMN1R52,DARC,GUCY1B3 |
| protein binding | FAM86A,CLPX,ROR1,LYN,CALCOCO2,TBKBP1,NCL,HPSE,UBE2E3,ITGA7 |
Interacting Protein
MCC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCC here. Most of them are supplied by our site. Hope this information will be useful for your research of MCC.
CSNK1E;SCRIB;EZR;NFKBIB;GTF2E2;20475405
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