MC3R
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Official Full Name
melanocortin 3 receptor -
Overview
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008] -
Synonyms
MC3R;melanocortin 3 receptor;MC3;OB20;OQTL;BMIQ9;MC3-R;melanocortin receptor 3;obesity quantitative trait locus
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
Involved Pathway
MC3R involved in several pathways and played different roles in them. We selected most pathways MC3R participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MC3R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | P2RY13,RXFP4,GRIA3A,P2RY4,CHRNA1,LEPA,CALCRLA,GRIA2,APLNRA,CCKAR |
Protein Function
MC3R has several biochemical functions, for example, melanocortin receptor activity,melanocyte-stimulating hormone receptor activity,neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MC3R itself. We selected most functions MC3R had, and list some proteins which have the same functions with MC3R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C1QTNF9,CETN2,SPAG8,KMT2E,NEFM,GAS2L3,PTBP3,FIGNL1,RELL2,CCT6A |
| neuropeptide binding | OPRD1B,MRGPRX2,OPRK1,GPR149,MC4R,SSTR5,SSTR4,OPRD1,SSTR2,SSTR1 |
| peptide hormone binding | AGTR2,ACVR1,MAS1,GHR,GCGR,GHRHR,AVPR1A,AGTR1B,ECE1,OXTR |
| melanocyte-stimulating hormone receptor activity | MC4R,MC1R |
| melanocortin receptor activity | MC5RB,MC2R,MC4R,MC5R,MC1R,MC5RA |
Interacting Protein
MC3R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MC3R here. Most of them are supplied by our site. Hope this information will be useful for your research of MC3R.
MRAP;MRAP2
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References
- Peter, JC; Zipfel, G; et al. Antibodies raised against different extracellular loops of the melanocortin-3 receptor affect energy balance and autonomic function in rats. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 30:444-453(2010).
- Getting, SJ; Lam, CW; et al. [D-Trp(8)]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). MOLECULAR PHARMACOLOGY 70:1850-1855(2006).
