Mbl1

  • Official Full Name

    mannose-binding lectin (protein A) 1

  • Overview

    MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa andfungi. Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system.Another important function of MBL is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes.

  • Synonyms

    MBL1;mannose-binding lectin (protein A) 1;mannose-binding protein A;mannose binding lectin (A);MBP A;S MBP;raRF p28B;mannan-binding protein;mannose binding lectin, serum (A);ra-reactive factor polysaccharide-binding component p28B;MBL-A;MBP-A;S-MBP

Recombinant Proteins

  • Mouse
  • Rat
  • HEK293
  • Human Cells
  • Mammalian Cells
  • Insect Cells
  • His
  • Non
  • Fc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
Mbl1-803M Recombinant Mouse MBL1 protein(Ser18-Ala239), His-tagged HEK293 Mouse His 18-239 a.a.
Mbl1-20R Recombinant Rat Mbl1, Fc tagged Human Cells Rat His 1-238 a.a.
MBL1-3602R Recombinant Rat MBL1 Protein Mammalian Cells Rat His
MBL1-1113RCL Recombinant Rat MBL1 cell lysate Human Cells Rat Non
MBL1-2776MCL Recombinant Mouse MBL1 cell lysate Human Cells Mouse Non
Mbl1-0145M Recombinant Mouse Mbl1 Protein (Ser18-Ala239), C-His-tagged Insect Cells Mouse His Ser18-Ala239
MBL1-1286R Recombinant Rat MBL1 protein(Met1-Ala238), hFc-tagged HEK293 Rat Fc Met1-Ala238
MBL1-3258R Recombinant Rat MBL1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
MBL1-3258R-B Recombinant Rat MBL1 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    Mbl1 involved in several pathways and played different roles in them. We selected most pathways Mbl1 participated on our site, such as Phagosome,Complement and coagulation cascades,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Mbl1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Staphylococcus aureus infection ICAM1,FCAR,FCGR2A,HLA-DOB,ITGAM,HLA-DRA,SELP,MASP1,HLA-DQB1,CFB
    Complement and coagulation cascades C1S,C4BPA,CFB,F2,CFD,F9,KLKB1,C1QB,SERPINA1A,PROC
    Phagosome CANX,MHC2DCB,CD36,MHC2DAB,TUBA1L,THBS3,COLEC12,FAM49BA,MRC2,ITGB2

    Protein Function

    Mbl1 has several biochemical functions, for example, calcium ion binding,calcium-dependent protein binding,carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Mbl1 itself. We selected most functions Mbl1 had, and list some proteins which have the same functions with Mbl1. You can find most of the proteins on our site.

    Function Related Protein
    protease binding SERPINB13,Casp3,ADAM8A,MALT1,CST3,DVL3,UBC,MBP,NDUFS7,FLOT1
    polysaccharide binding ENPP1,PRG4B,TINAG,TINAGL1,PRG4A,VTN,CLEC18C,VTNB,PRG4,ENDOU
    carbohydrate binding CLEC2H,CLEC4A,MRC2,Pla2r1,REG3G,CLEC18B,CD34,SIGLEC11,CLEC4E,GALNT14
    protein homodimerization activity GOT2,QDPR,HMOX1,NLGN4X,DMRT2A,PML,FAP,LHPP,MAP3K12,ERCC5
    mannose binding LMAN1,DPM1,CD209C,CLN5,COLEC10,MAN2B1,CD209B,MANBA,BSG,CD209A
    calcium-dependent protein binding MASP2,S100A6,CD209A,MYO5A,KOP,SELP,VAMP2,SEC31A,TNNT3,CASQ2
    phosphatidylinositol-4-phosphate binding RS1,D6WSU116E,CLSTN2,FAM21C,JPH2,GOLPH3,COL4A3BP,OSBPL5,PLEKHF1,PLEKHA8
    calcium ion binding CDHR1,PCDH2G1,DUOX2,ANXA13,FBLN1,TPO,PCDH10A,S100U,SPTA1,PCDH1G3

    Interacting Protein

    Mbl1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mbl1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Mbl1.

    Resources

    Research Area

    Acute Phase Proteins

    References

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