MBD5
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Official Full Name
methyl-CpG binding domain protein 5 -
Overview
This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. -
Synonyms
MBD5;methyl-CpG binding domain protein 5;methyl-CpG-binding domain protein 5;FLJ11113;KIAA1461;methyl-CpG-binding protein MBD5;MRD1;FLJ30517
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MBD5-764H | Recombinant Human MBD5, His-tagged | E.coli | Human | His | 1-292aa | |
| MBD5-2693R | Recombinant Rhesus monkey MBD5 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MBD5-1066HCL | Recombinant Human MBD5 cell lysate | Human | Non |
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| MBD5-2513R | Recombinant Rhesus Macaque MBD5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| MBD5-2513R-B | Recombinant Rhesus Macaque MBD5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
MBD5 involved in several pathways and played different roles in them. We selected most pathways MBD5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
MBD5 has several biochemical functions, for example, NOT DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD5 itself. We selected most functions MBD5 had, and list some proteins which have the same functions with MBD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT DNA binding | NFIB,HIPK2,SKIL,TINF2,XRCC4 |
| chromatin binding | TCF3,PARP1,CBFA2T3,SIN3A,ASF1A,LMO2,TLE4,KIAA0101,AJUBA,CBX1 |
Interacting Protein
MBD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD5.
APC;mexB;vgrG5;epd;flgE;chi36;yqgS;mdlB6;fadL;acrA1;lipB;KIAA1549;ureC
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References
- Xu, ZN; Yin, HS; et al. Electrochemical immunosensor for DNA methyltransferase activity assay based on methyl CpG-binding protein and dual gold nanoparticle conjugate-based signal amplification. SENSORS AND ACTUATORS B-CHEMICAL 192:143-149(2014).
- Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
