MBD3
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Official Full Name
methyl-CpG binding domain protein 3 -
Overview
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] -
Synonyms
MBD3;methyl-CpG binding domain protein 3;methyl-CpG-binding domain protein 3
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His&T7
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MBD3-223H | Recombinant Human MBD3 protein, T7/His-tagged | E.coli | Human | His&T7 | 259 a.a. |
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| MBD3-2692R | Recombinant Rhesus monkey MBD3 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MBD3-28525TH | Recombinant Human MBD3, His-tagged | E.coli | Human | His | 164-291 a.a. |
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| MBD3-3583C | Recombinant Chicken MBD3 | Mammalian Cells | Chicken | His |
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| MBD3-7179H | Recombinant Human Methyl-CpG Binding Domain Protein 3, His-tagged | E.coli | Human | His | 1-291aa |
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| MBD3-1065HCL | Recombinant Human MBD3 cell lysate | Human | Non |
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| MBD3-2512R | Recombinant Rhesus Macaque MBD3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| MBD3-2512R-B | Recombinant Rhesus Macaque MBD3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
MBD3 involved in several pathways and played different roles in them. We selected most pathways MBD3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA Polymerase I Promoter Clearance | EHMT2,GATAD2A,RRN3,TAF1D,CD3EAP,TAF1C,UBTF,MBD3B,TAF1A,MTA2 |
| RNA Polymerase I Transcription | CHD4A,GATAD2AB,PTRF,PTRFB,CHD4,TAF1B,TAF1D,UBTF,TAF1A,MBD3B |
| Chromatin organization | KDM5B,BRPF1,SUDS3,ING5B,SMYD3,KAT7B,PADI6,GATAD2A,KDM3B,MTA2 |
| HDACs deacetylate histones | ARID4A,GATAD2AB,SAP30L,MTA1,GATAD2B,KDM1A,ANO9A,CHD4,MBD3B,SUDS3 |
| RNA Polymerase I Transcription Initiation | MTA1,CHD4,GATAD2A,MTA2,MBD3A,GATAD2AB,MTA3,CHD4A,GATAD2B,RRN3 |
| Chromatin modifying enzymes | SUZ12B,SAP30L,KAT8,CCDC101,KAT7,JMJD6,MSL3,KDM6B,SMARCB1A,ARID5B |
| Gene Expression | EEF1E1,CLP1,TRIM28,EIF3K,ZNF354A,MAEL,LCMT2,ZNF287,HNRPL,USP9X |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | BRF1,GATAD2B,POLRMT,SNAPC1A,CRCP,NFIC,PTRF,BRF1B,GTF3A,SNAPC1 |
Protein Function
MBD3 has several biochemical functions, for example, DNA binding,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding,contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD3 itself. We selected most functions MBD3 had, and list some proteins which have the same functions with MBD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP513,PPARG,SOX21B,CARF,BANP,NR2F6B,MXI1,ZNF501,EF1,KLF3 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | RBBP4,SMARCC2,SMARCB1,SMARCC1,ACTL6A,HDAC2,SMARCE1,HDAC1,CHD4,SMARCA4 |
| protein binding | MRPS6,SNX33,GNA12,GBP2,NHP2,CLEC16A,CYLD,EPM2AIP1,CD47,MED23 |
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | ACTL6A,SMARCA4,GATAD2B,SMARCC1,HDAC2,RBBP4,MTA2,CHD4,SMARCB1,SMARCE1 |
| contributes_to nucleosomal DNA binding | SMARCC1,CHD4,RBBP4,SMARCE1,HDAC2,ACTL6A,ACTB,SMARCC2,GATAD2B,SMARCA4 |
| methyl-CpG binding | ZBTB33,MBD3A,ZBTB4,DNMT1,MECP2,UHRF1,MBD1B,MBD3L1,LRWD1,ZNF295 |
Interacting Protein
MBD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD3.
HDAC1;HDAC2;GATAD2B;MTA2;MTA3
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References
- Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).
- Lei, W; Luo, Y; et al. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:369-374(2009).
