Marco
-
Official Full Name
macrophage receptor with collagenous structure -
Overview
Macrophage receptor MARCO is a protein that in humans is encoded by the MARCO gene. The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an intracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. -
Synonyms
MARCO;SCARA2;Macrophage receptor MARCO;Macrophage receptor with collagenous structure;MARCO_HUMAN;Scavenger receptor class A member 2
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Cynomolgus
- E.coli
- Mammalian Cells
- CHO
- HEK293
- Human Cells
- His
- His&T7
- Non
- Avi&Fc&His
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MARCO-750H | Recombinant Human MARCO, His-tagged | E.coli | Human | His | C-term-350aa | |
| Marco-589M |
Active Recombinant Mouse Marco protein, His-tagged
|
Mammalian Cells | Mouse | His | 70-518 a.a. |
|
| MARCO-5940H |
Active Recombinant Human MARCO protein, His-tagged
|
CHO | Human | His | 79-520 a.a. |
|
| Marco-2229M | Recombinant Mouse Marco protein, His-tagged | HEK293 | Mouse | His | Gln70-Ser518 |
|
| MARCO-6301C | Recombinant Chicken MARCO | Mammalian Cells | Chicken | His |
|
|
| Marco-7944M | Recombinant Mouse Marco protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gly366~Ser518 |
|
| Marco-7945R | Recombinant Rat Marco protein, His & T7-tagged | E.coli | Rat | His&T7 | Gly367~Arg519 |
|
| MARCO-2563MCL | Recombinant Mouse MARCO cell lysate | Human Cells | Mouse | Non |
|
|
| MARCO-0516M | Recombinant Mouse MARCO protein, His-tagged | HEK293 | Mouse | His | 70-518 a.a. |
|
| MARCO-2149H | Recombinant Human MARCO protein, His-tagged | HEK293 | Human | His | Met 79 - Val 520 |
|
| MARCO-2156C | Recombinant Cynomolgus MARCO protein, His-tagged | HEK293 | Cynomolgus | His | Met 79 - Ile 520 |
|
| MARCO-2163M | Recombinant Mouse MARCO protein, His-tagged | HEK293 | Mouse | His | Gln70-Ser518 |
|
| MARCO-2208M | Recombinant Mouse MARCO protein, His-tagged | HEK293 | Mouse | His | Gln 421 - Ser 518 |
|
| MARCO-5235H | Recombinant Human MARCO Protein (Met79-Val520), N-His tagged | E.coli | Human | His | Met79-Val520 |
|
| Marco-5371M | Recombinant Mouse Marco Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
|
| Marco-5371M-B | Recombinant Mouse Marco Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| MARCO-7854H | Recombinant Human MARCO protein, His-tagged | HEK293 | Human | His | Ser405-Val520 |
|
| MARCO-8734H | Recombinant Human MARCO protein, GST-tagged | E.coli | Human | GST |
|
|
| MARCO-8735H | Recombinant Human MARCO protein, His-tagged | E.coli | Human | His |
|
Involved Pathway
Marco involved in several pathways and played different roles in them. We selected most pathways Marco participated on our site, such as Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Marco were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | RAC1,MSR1,CD14,RAB5AB,C3A.1,LAMP2,M6PR,RAB5AA,RAB7,ATP6V0E2 |
Protein Function
Marco has several biochemical functions, for example, scavenger receptor activity,signaling pattern recognition receptor activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Marco itself. We selected most functions Marco had, and list some proteins which have the same functions with Marco. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | SORL1,GHRHRA,FZD8B,CLDN3,ENG,NCR2,GPR126,CLEC2D,ANTXR1,TNFRSF10C |
| signaling pattern recognition receptor activity | TLR2,CLEC7A,COLEC12,TRIM5,DMBT1,FCN1 |
| scavenger receptor activity | PRG4B,SRCRB4D,SCARF1,CFI,LGALS3BPB,TMPRSS4A,CD163,CXCR7,LOXL3,VTNA |
Interacting Protein
Marco has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Marco here. Most of them are supplied by our site. Hope this information will be useful for your research of Marco.
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References
- Verschoor, CP; Dorrington, MG; et al. MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx. INFECTION AND IMMUNITY 82:4824-4833(2014).
- Majumder, PP; Sarkar-Roy, N; et al. Genomic correlates of variability in immune response to an oral cholera vaccine. EUROPEAN JOURNAL OF HUMAN GENETICS 21:1000-1006(2013).
