MARCKS
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Official Full Name
myristoylated alanine-rich protein kinase C substrate -
Overview
Myristoylated alanine-rich C-kinase substrate (MARCKS) is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. -
Synonyms
MARCKS;myristoylated alanine-rich protein kinase C substrate;MACS, myristoylated alanine rich protein kinase C substrate (MARCKS, 80K L);myristoylated alanine-rich C-kinase substrate;80K L;PKCSL;phosphomyristin;protein kinase C substrate, 80 kDa protein, light chain;myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L);MACS;80K-L;PRKCSL;FLJ14368;FLJ90045
Recombinant Proteins
- Human
- Chicken
- Mouse
- Bovine
- HEK293
- Wheat Germ
- Mammalian Cells
- E.coli
- Bovine brain
- Myc&DDK
- GST
- His
- His&SUMO
- Non
- His&Fc&Avi
- Flag
Involved Pathway
MARCKS involved in several pathways and played different roles in them. We selected most pathways MARCKS participated on our site, such as Fc gamma R-mediated phagocytosis,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc gamma R-mediated phagocytosis | FCGR3A,PIK3CA,SPHK1,FCGR1,PLD1,VAV3,PLD2,PPAP2C,LIMK2,AMPH |
| MicroRNAs in cancer | ZEB2,IKBKB,TRP53,MTOR,VIM,TNN,RHOA,PDGFRB,VEGFA,CCNG1 |
Protein Function
MARCKS has several biochemical functions, for example, actin filament binding,calmodulin binding,protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCKS itself. We selected most functions MARCKS had, and list some proteins which have the same functions with MARCKS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin filament binding | TRIOBPB,CORO1CA,SVIL,MYL4,MYO18A,ACTN4,CORO1B,CORO6,ANTXR1,TRIOBP |
| protein kinase C binding | HDAC7A,PDLIM5,GNB2L1,PLEK,TIRAP,AKT2,TOP2B,SDC4,SDPRB,AVPR1B |
| calmodulin binding | KCNN4,TTN,SNTA1,PHKG1A,DCX,PPP3CA,CAMK1,ADD2,CAMK2D1,MKNK1 |
Interacting Protein
MARCKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCKS here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCKS.
CNOT8;TRAF6;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;ssrna_ug;MAPK13;PTBP3;cona_canen;NS;ATF2;polg_hcvh
Resources
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References
- Tinoco, LW; Fraga, JL; et al. Structural characterization of a neuroblast-specific phosphorylated region of MARCKS. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:837-849(2014).
- Contreras-Vallejos, E; Utreras, E; et al. Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5(-/-) Mice. PLOS ONE 9:-(2014).
