MARCH5
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Official Full Name
membrane-associated ring finger (C3HC4) 5 -
Overview
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]). -
Synonyms
membrane-associated ring finger (C3HC4) 5;Mitochondrial ubiquitin ligase;RING finger protein 153;MITOL;MARCH-V;RNF153;FLJ20445;Membrane-associated RING finger protein 5;EC 6.3.2.-;Membrane-associated RING-CH protein V;EC 6.3.2;E3 ubiquitin-protein ligase MARCH5;OTTHUMP00000020096;MARCH5
Recombinant Proteins
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- Human
- Bovine
- Chlorocebus Aethiops
- Xenopus laevis
- zebrafish
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
MARCH5 involved in several pathways and played different roles in them. We selected most pathways MARCH5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MARCH5 has several biochemical functions, for example, GTPase binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCH5 itself. We selected most functions MARCH5 had, and list some proteins which have the same functions with MARCH5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | RLIM,LTN1,ANKIB1A,FBXO30A,UBE2E1,UBE2E3,RNF220,BRAP,WWP2,RNF135 |
| protein binding | ANGPTL4,ADCK5,TTC39B,ADRA2C,ING2,MYOCD,ITPKB,HDAC5,PEX2,ELP4 |
| zinc ion binding | NEURL1B,ZFAND5,CA4,QPCTLA,TRIM35-28,ZDHHC16,USP5,SP140L,ZDHHC14,RXRBB |
| ligase activity | ZNRF3,UBE2G1B,C12orf51,TRIP12,HERC2,CCNB1IP1,RNF43,PET112L,RNF34,TRIM58 |
| GTPase binding | ENO1,VPS41,RASA1,EPRS,GM5506,AIMP1,LCP1,STOML2,GNB2,IARS |
Interacting Protein
MARCH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCH5.
UBE2W;DENR;FATE1;UBE2W;UBC;MFN2;FIS1;CREB3;UBE2N;UBE2I;AKTIP
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References
- Zemirli, N; Pourcelot, M; et al. Mitochondrial hyperfusion promotes NF-kappa B activation via the mitochondrial E3 ligase MULAN. FEBS JOURNAL 281:3095-3112(2014).
- Choudhary, V; Kaddour-Djebbar, I; et al. Mitofusin 1 degradation is induced by a disruptor of mitochondrial calcium homeostasis, CGP37157: A role in apoptosis in prostate cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY 44:1767-1773(2014).
