MARCH2
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Official Full Name
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase -
Synonyms
MARCH2;membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase;28038;ENSG00000099785;RNF172;HSPC240;MARCH-II;19p13.2;E3 ubiquitin-protein ligase MARCH2;E3 ubiquitin-protein ligase MARCH2;RING finger protein 172;membrane-associated RING-CH protein II;membrane-associated RING finger protein 2;EC 6.3.2.-
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Xenopus laevis
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mus musculus
- zebrafish
- Bovine
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&SUMO
- His&Fc&Avi
Involved Pathway
MARCH2 involved in several pathways and played different roles in them. We selected most pathways MARCH2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MARCH2 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCH2 itself. We selected most functions MARCH2 had, and list some proteins which have the same functions with MARCH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRAF4,KAT6B,PITRM1,TRIM7,C6AST1,PDLIM4,LHX8,PHF21A,TRIM55B,ZBTB32 |
| protein binding | RAB18,NUAK1,FOSL2,CHRM3,NPPA,ITGB2,ARNTL1A,IFT20,FAM49B,HCFC1 |
| ligase activity | RLIM,ARIH2,DZIP3,RNF212,MARCH9,PDZRN3,IRF2BP1,SHPRH,TRAF7,UBE2I |
| ubiquitin-protein transferase activity | UBE2G2,BTR22,HERC2,CBL,RNF13,ANKIB1A,RNF31,NSMCE1,UBE2L6,TRIP12 |
Interacting Protein
MARCH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCH2.
LDLRAD1;SYNE4;CCDC155;FATE1
Resources
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References
- Wang, G; Liu, J; et al. MARCH2: Comparative Assessment of Therapeutic Effects of Acarbose and Metformin in Newly Diagnosed Type 2 Diabetes Patients. PLOS ONE 9:-(2014).
- Cheng, J; Guggino, W; et al. Ubiquitination and Degradation of CFTR by the E3 Ubiquitin Ligase MARCH2 through Its Association with Adaptor Proteins CAL and STX6. PLOS ONE 8:-(2013).
