MAPK4

  • Official Full Name

    mitogen-activated protein kinase 4

  • Overview

    Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region. However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, poss Encodes a nuclear and cytoplasmically localized MAP kinase involved in mediating responses to pathogens. Its substrates include MKS1 and probably MAP65-1.The MAP65-1 interaction is involved in mediating cortical microtuble organization.

  • Synonyms

    MAPK4;mitogen-activated protein kinase 4;PRKM4;Erk3 related;Erk4;ERK-4;MAPK 4;p63-MAPK;Erk3-related;MAP kinase 4;MAP kinase isoform p63;extracellular signal-regulated kinase 4;ERK3;p63MAPK;MPK4;ATMPK4;MAP kinase 4 (MPK4);FUNCTIONS IN: MAP kinase activity, kinase activity;INVOLVED IN: in 14 processes;LOCATED IN: nucleus, cytoplasm;EXPRESSED IN: 24 plant structures;EXPRESSED DURING: 13 growth stages;BEST Arabidopsis thaliana protein match is: MAP kinase 11 (TAIR:AT1G01560.2);Has 123445 Blast hits to 122024 proteins in 4656 species: Archae - 100;Bacteria - 13145;Metazoa - 47072;Fungi - 12439;Plants - 29862;Viruses - 477;Other Eukaryotes - 20350 (source: NCBI BLink).;F2N1.1;F2N1_1

Recombinant Proteins

  • Zebrafish
  • Rhesus macaque
  • Mouse
  • Human
  • Mammalian Cell
  • HEK293
  • Insect Cell
  • HEK293T
  • His
  • Non
  • His&GST
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAPK4-12640Z Recombinant Zebrafish MAPK4 Mammalian Cell Zebrafish His
MAPK4-2673R Recombinant Rhesus monkey MAPK4 Protein, His-tagged Mammalian Cell Rhesus macaque His
MAPK4-9535M Recombinant Mouse MAPK4 Protein Mammalian Cell Mouse His
MAPK4-4493HCL Recombinant Human MAPK4 293 Cell Lysate HEK293 Human Non
MAPK4-0110H Recombinant Human MAPK4 Protein (A2-W587), Tag Free Insect Cell Human Non A2-W587
MAPK4-0111H Recombinant Human MAPK4 Protein (A2-W587), His/GST tagged Insect Cell Human His&GST A2-W587
MAPK4-2276H Recombinant Human MAPK4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
MAPK4-2493R Recombinant Rhesus Macaque MAPK4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MAPK4-2493R-B Recombinant Rhesus Macaque MAPK4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Mapk4-3943M Recombinant Mouse Mapk4 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
MAPK4-5351M Recombinant Mouse MAPK4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
MAPK4-5351M-B Recombinant Mouse MAPK4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MAPK4 involved in several pathways and played different roles in them. We selected most pathways MAPK4 participated on our site, such as B Cell Receptor Signaling Pathway,Focal Adhesion,Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integrated Pancreatic Cancer Pathway MST1,WRN,TOP1,JUND,TOP2A,CASP12,IL11,PPP1R13L,DAXX,FKBP1B
    Integrin-mediated cell adhesion CAPN5,CAPN11,SEPP1,CAPNS1,CAPN3A,TNS1,CAPN3,CAPN9,SEPP1A,MAPK6
    Focal adhesion FIGF,CDC42,FLNB,ACTN2,VTNA,RAPGEF1,MAPK9,LAMC2,CAPN2A,PIK3R5
    MAPK signaling pathway BDNF,CACNB4A,PRKACBB,GADD45G,JIP1,MAPK8A,RASGRP3,RAC2,MAP2K2,Fasl
    MAPK family signaling cascades CDC42EP5,IGF2BP1,CDC42EP1B,CDC42EP2,MAPK6,CDC42EP3,SEPT7
    MAPK6/MAPK4 signaling CDC42EP1B,SEPT7,CDC42EP3,CDC42EP5,IGF2BP1,CDC42EP2,MAPK6
    Insulin Signaling SNAP25A,MAP3K10,STXBP4,RRAD,MAP4K5,FLOT1,GRB10,MAP3K9,STXBP1A,RHOJ
    B Cell Receptor Signaling Pathway MAPK3,CRKL,PIK3CD,PDK2B,CARD11,CDK7,LYN,CSK,DUSP6,PIK3R1

    Protein Function

    MAPK4 has several biochemical functions, for example, ATP binding,MAP kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK4 itself. We selected most functions MAPK4 had, and list some proteins which have the same functions with MAPK4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding IDE,UBE2J1,MOS,ACTB,ATP10A,ACTR8,WARS,NAGK,KCNJ10,Abca2
    protein heterodimerization activity SLC51A,BHLHE40,HEXA,CLCF1,HIST1H2BP,HMG20B,PVRL1,TAP1,CRLF1,TENM2
    protein homodimerization activity OSTA,WWTR1,CHRNA7,MAOB,XDH,CIB2,LRP6,Fzd4,CER1,GIPC1
    MAP kinase activity MAPK11,MAPK1,MAPK12A,MAPK15,MAPK6,NLK,MAPK7,MAPK12,MAPK13,MAPK8B
    protein kinase binding SNAP91,PRC1,PRKAG2,FER,FAM83A,PRKRIP1,KIF13B,ADCY6,PRKAG1,RAB11FIP2
    protein binding ZNF133,NRCAM,SHANK3,DCTN3,DLC1,HIST1H2BF,SLC8A1,DPM3,CCDC59,TPP1
    protein serine/threonine kinase activity CLK3,ZNF143B,MAP2K7,RPS6KA3A,HIPK4,IRAK2,CDK15,CLK4,PKMYT1,RAF1B

    Interacting Protein

    MAPK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK4.

    HSP90AB1;CALML3;CRK;PSMA7;ATP1A1;PFKP;FASTKD5;ERC1;MAPKAPK5;FAM57A;TECR

    Resources

    Research Area

    ERK (Extracellular Signal-regulated Kinases)

    References

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