MAPK4

  • Official Full Name

    mitogen-activated protein kinase 4

  • Overview

    Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region. However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, poss Encodes a nuclear and cytoplasmically localized MAP kinase involved in mediating responses to pathogens. Its substrates include MKS1 and probably MAP65-1.The MAP65-1 interaction is involved in mediating cortical microtuble organization.

  • Synonyms

    MAPK4;mitogen-activated protein kinase 4;PRKM4;Erk3 related;Erk4;ERK-4;MAPK 4;p63-MAPK;Erk3-related;MAP kinase 4;MAP kinase isoform p63;extracellular signal-regulated kinase 4;ERK3;p63MAPK;MPK4;ATMPK4;MAP kinase 4 (MPK4);FUNCTIONS IN: MAP kinase activity, kinase activity;INVOLVED IN: in 14 processes;LOCATED IN: nucleus, cytoplasm;EXPRESSED IN: 24 plant structures;EXPRESSED DURING: 13 growth stages;BEST Arabidopsis thaliana protein match is: MAP kinase 11 (TAIR:AT1G01560.2);Has 123445 Blast hits to 122024 proteins in 4656 species: Archae - 100;Bacteria - 13145;Metazoa - 47072;Fungi - 12439;Plants - 29862;Viruses - 477;Other Eukaryotes - 20350 (source: NCBI BLink).;F2N1.1;F2N1_1

Recombinant Proteins

  • Zebrafish
  • Rhesus macaque
  • Mouse
  • Human
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • His
  • Non
  • GST
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAPK4-12640Z Recombinant Zebrafish MAPK4 Mammalian Cells Zebrafish His
MAPK4-2673R Recombinant Rhesus monkey MAPK4 Protein, His-tagged Mammalian Cells Rhesus macaque His
MAPK4-9535M Recombinant Mouse MAPK4 Protein Mammalian Cells Mouse His
MAPK4-4493HCL Recombinant Human MAPK4 293 Cell Lysate HEK293 Human Non
MAPK4-0110H Recombinant Human MAPK4 Protein (A2-W587), Tag Free Insect Cells Human Non A2-W587
MAPK4-0111H Recombinant Human MAPK4 Protein (A2-W587), His/GST tagged Insect Cells Human GST&His A2-W587
MAPK4-2276H Recombinant Human MAPK4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
MAPK4-2493R Recombinant Rhesus Macaque MAPK4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MAPK4-2493R-B Recombinant Rhesus Macaque MAPK4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Mapk4-3943M Recombinant Mouse Mapk4 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
MAPK4-5351M Recombinant Mouse MAPK4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MAPK4-5351M-B Recombinant Mouse MAPK4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MAPK4 involved in several pathways and played different roles in them. We selected most pathways MAPK4 participated on our site, such as B Cell Receptor Signaling Pathway,Focal Adhesion,Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling Pathway PPP3CB,VAV1,PIK3CB,HRAS,RELA,ARPC3,BLNK,SYK,PTPN6,MALT1
    MAPK signaling pathway C11orf52,RAC3B,GADD45AB,FGF10,MAPK8A,RAC1A,NFKB2,PPM1A,CACNG8,CACNB2
    Integrin-mediated cell adhesion SEPP1A,MYLK2,CAPN3,CAPNS1,CAPN3A,MAPK6,SEPP1,CAPN10,TNS1,CAPN5
    Insulin Signaling ARHGAP33,GSK3AB,STXBP2,MAPK6,GRB14,MYO1C,MAP3K2,EHD1,KIF5B,RRAD
    Integrated Pancreatic Cancer Pathway TOP1,TFF1,AGA,MYT1,DAXX,FKBP3,NOXA1,FST,RB1CC1,PPP1R13L
    MAPK family signaling cascades MAPK6,CDC42EP5,IGF2BP1,CDC42EP1B,CDC42EP3,SEPT7,CDC42EP2
    Focal adhesion VEGFAA,PDGFAA,PAK2A,PAK6,ACTN2B,PRKCB,PARVG,PPP1R12B,FYNA,IGF1
    MAPK6/MAPK4 signaling CDC42EP2,CDC42EP1B,SEPT7,CDC42EP3,IGF2BP1,MAPK6,CDC42EP5

    Protein Function

    MAPK4 has several biochemical functions, for example, ATP binding,MAP kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK4 itself. We selected most functions MAPK4 had, and list some proteins which have the same functions with MAPK4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding BMPR2,LRRK1,ATP1A4,HIPK1,ATP2A2,PIP5K1A,PRKACG,P2RX2,VARS2,PDIK1L
    protein binding DARS,DPEP1,SOD1,GTF2IRD2,SH2D1A,ADCYAP1,ANXA6,TCEA1,RASSF4,MMP2
    protein heterodimerization activity PDSS2,NEUROD2,TAF6L,GRIN2A,H3F3A,MAP3K7,CABYR,SUPT3H,POU5F3,NAE1
    protein serine/threonine kinase activity CSNK1DB,AKT3A,CSNK1A1L,MAP3K9,CIT,TSSK1,HIPK1,CSNK1G1,CAMK1GA,ADCK5
    protein homodimerization activity SRF,CEBPA,PRMT2,FBXO4,IKBKG,EPHX2,TBX18,HNF1A,BAX,CBX5
    MAP kinase activity MAPK6,MAPK11,MAPK14,MAPK12A,NLK,MAPK12,MAPK3,MAPK15,MAPK8A,MAPK14A
    protein kinase binding CCNL1,APC,SPDYE2,CDK5R1,CDC25A,CDH2,CD4,CSPG4,TSKS,ACVRL1

    Interacting Protein

    MAPK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK4.

    HSP90AB1;CALML3;CRK;PSMA7;ATP1A1;PFKP;FASTKD5;ERC1;MAPKAPK5;FAM57A;TECR

    Resources

    Research Area

    ERK (Extracellular Signal-regulated Kinases)

    References

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