MAN2B1
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Official Full Name
mannosidase, alpha, class 2B, member 1 -
Overview
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MAN2B1;mannosidase, alpha, class 2B, member 1;MANB;lysosomal alpha-mannosidase;LAMAN;EC 3.2.1.24;Lysosomal acid alpha mannosidase;Lysosomal alpha mannosidase;Mannosidase alpha class 2B member 1;Mannosidase, alpha B;Mannosidase, alpha B, lysosomal;mannosidase alpha-B;lysosomal acid alpha-mannosidase
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&T7
- Myc&DDK
- Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAN2B1-2719H | Recombinant Human MAN2B1 protein, His-tagged | E.coli | Human | His | 51-342 aa | |
| MAN2B1-2257Z | Recombinant Zebrafish MAN2B1 | Mammalian Cells | Zebrafish | His |
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| MAN2B1-9486M | Recombinant Mouse MAN2B1 Protein | Mammalian Cells | Mouse | His |
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| MAN2B1-4524HCL | Recombinant Human MAN2B1 293 Cell Lysate | HEK293 | Human | Non |
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| MAN2B1-1550H | Recombinant Human MAN2B1 protein, His & T7-tagged | E.coli | Human | His&T7 | Ala883~Gly1011 |
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| Man2b1-3914M | Recombinant Mouse Man2b1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MAN2B1-4289H | Recombinant Human MAN2B1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MAN2B1-43HFL | Recombinant Full Length Human mannosidase, alpha, class 2B, member 1 Protein, Flag tagged | HEK293 | Human | Flag | Full L. 1-1011aa |
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| MAN2B1-5316M | Recombinant Mouse MAN2B1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MAN2B1-5316M-B | Recombinant Mouse MAN2B1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MAN2B1 involved in several pathways and played different roles in them. We selected most pathways MAN2B1 participated on our site, such as Other glycan degradation,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAN2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other glycan degradation | NEU3,GBA2,NEU2,NEU4,FUCA1,NEU1,AGA,ENG-1,FUCA1.1,NEU3.1 |
| Lysosome | ATP6V0CB,NAGLU,HYAL1,NAGA,AP3S1,SGSH,ASAH1B,SORT1B,TPP1,AP4B1 |
Protein Function
MAN2B1 has several biochemical functions, for example, alpha-mannosidase activity,mannose binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAN2B1 itself. We selected most functions MAN2B1 had, and list some proteins which have the same functions with MAN2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-mannosidase activity | MAN2A2,MAN2B2,MAN2C1 |
| zinc ion binding | AGBL5,SPG7,SLC30A7,YY1,BRAP,ABP1,P2RX4,VPS11,RNF169,TNP2 |
| mannose binding | Acr,CD209A,DPM1,CD209,LMAN2L,CD209B,MANBA,CLN5,CD209C,CD207 |
Interacting Protein
MAN2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAN2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAN2B1.
L2;L2;cona_canen
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References
- Natiq, A; Elalaoui, SC; et al. A new case of de novo 19p13.2p13.12 deletion in a girl with overgrowth and severe developmental delay. MOLECULAR CYTOGENETICS 7:-(2014).
- Wu, XY; Pan, JX; et al. Molecular diagnosis of a Chinese pedigree with alpha-mannosidosis and identification of a novel missense mutation. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 27:491-495(2014).
