MAN1B1

  • Official Full Name

    mannosidase, alpha, class 1B, member 1

  • Overview

    Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene.

  • Synonyms

    MAN1B1;mannosidase, alpha, class 1B, member 1;endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase;alpha 1;2 mannosidase;endoplasmic reticulum alpha mannosidase 1;endoplasmic reticulum mannosyl oligosaccharide 1;2 alpha mannosidase

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • Mus musculus
  • HEK293
  • Mammalian Cells
  • E.coli
  • His
  • Non
  • His&Fc&Avi

    Involved Pathway

    MAN1B1 involved in several pathways and played different roles in them. We selected most pathways MAN1B1 participated on our site, such as Asparagine N-linked glycosylation,Calnexin/calreticulin cycle,ER Quality Control Compartment (ERQC), which may be useful for your reference. Also, other proteins which involved in the same pathway with MAN1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    N-Glycan biosynthesis ALG13,TUSC3,MAN1A1,ALG2,B4GALT1,MAN1A2,STT3A,FUT8A,MGAT3A,MGAT4C
    Metabolic pathways MAPK1IP1L,DPYD,TKTB,GALNT18A,ACOT5,PCYT1BA,PGD,B3GALT4,AMY2A4,CKM
    Asparagine N-linked glycosylation TRAPPC10,TFG,TRAPPC5,MCFD2,ST8SIA2,SEC16B,GORASP1,NSFA,ST6GAL2B,CTSZ
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle MLEC
    Calnexin/calreticulin cycle OS9,DERL2
    Post-translational protein modification ARSF,SCFD1,ALG14,ZNF408,PHC2,THSD7A,GALNT13,BET1,MPDU1A,NEU3
    ER Quality Control Compartment (ERQC) DERL2,OS9
    Metabolism of proteins VBP1,ADAMTS3,CCT7,TIMM21,SEC63,APEH,MUC4,DDIT3,SFTPB,MCFD2

    Protein Function

    MAN1B1 has several biochemical functions, for example, calcium ion binding,mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAN1B1 itself. We selected most functions MAN1B1 had, and list some proteins which have the same functions with MAN1B1. You can find most of the proteins on our site.

    Function Related Protein
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity EDEM1,EDEM2,MAN1A,MAN1A1,MAN1A2,MAN1C1
    calcium ion binding EHD1A,PCDH2G9,S100A13,CDK5R1,TNNC1B,SMOC2,RGN,CALR,TLL2,SLIT1B

    Interacting Protein

    MAN1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAN1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAN1B1.

    DNM2;N;Uso1

    Resources

    References

    • Peanne, R; Rymen, D; et al. MAN1B1-CDG: how stressed-out can the Golgi be?. GLYCOBIOLOGY 24:1105-1105(2014).
    • Haga, Y; et al. ER or Golgi?: Localization of ER Alpha 1,2-Mannosidase I. TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 26:103-105(2014).

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