MAGI2
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Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 2 -
Overview
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. -
Synonyms
MAGI2;membrane associated guanylate kinase, WW and PDZ domain containing 2;membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;ACVRIP1;AIP1;ARIP1;KIAA0705;MAGI 2;WW and PDZ domain-containing protein 2;Activin receptor interacting protein 1;Acvri1;Acvrinp1;AIP 1;Aip-1;Atrophin 1 interacting protein 1;Atrophin 1 interacting protein A;Atrophin-1-interacting protein 1;Atrophin-1-interacting protein A;MAGI-2;MAGI2_HUMAN;Membrane associated guanylate kinase 2;Membrane associated guanylate kinase inverted 2;Membrane associated guanylate kinase WW and PDZ domain containing 2;Membrane associated guanylate kinase WW and PDZ domain containing protein 2;Membrane-associated guanylate kinase;Membrane-associated guanylate kinase inverted 2;S SCAM;SSCAM
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
MAGI2 involved in several pathways and played different roles in them. We selected most pathways MAGI2 participated on our site, such as Rap signaling pathway,Tight junction,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAGI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | RRAS,YES1,MYH1B,TJP2A,ACTB2,MYH10,JAM3,RHOAC,CRB3A,CLDN10 |
| Rap signaling pathway | GNAO1,CALM3,MAP2K2,FPR1,FGF2,NRAS,GRIN1,MET,PFN3,AKT1 |
| TNF signaling pathway | MAPK3,TNFRSF1A,CREB5,Casp3,BIRC2,BAG4,RELA,SELE,MAPK10,CREB3L3 |
Protein Function
MAGI2 has several biochemical functions, for example, SMAD binding,beta-1 adrenergic receptor binding,phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGI2 itself. We selected most functions MAGI2 had, and list some proteins which have the same functions with MAGI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatase binding | DZIP3,ELFN2,DYSFIP1,PPP1R35,SMAD3,CRY2,MAPK3,CRY1,PPP1R27,MAST2 |
| type II activin receptor binding | INHBA |
| signal transducer activity | CAPN3,OLFR488,TAS2R143,GPR89,GOLT1B,HTR1AA,VMN1R47,TAAR14H,OLFR150,TAAR13B |
| receptor signaling complex scaffold activity | DEDD2,LDLRAP1,SPAG9,NUP62,NCK1,SHANK1,SPAG9A,GRIP1,MAPK8IP3,GRIP2A |
| protein binding | NOTCH4,AAK1,IFIT3,CETN3,C5,FZD3,NRSN1,PIN4,CUBN,MLKL |
| beta-1 adrenergic receptor binding | DLG4 |
| SMAD binding | FKBP1A,STUB1,PURB,PML,CTNNB1,BMPR1B,SKI,TCF12,SKOR1A,CREBBP |
Interacting Protein
MAGI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGI2.
ADRB1;RAPGEF2;TGFA;POLR2A;POLR2B;AMOTL1;q8clu2_yerpe;DSCAML1;PLXNB3
Resources
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References
- Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).
- McGovern, DPB; Taylor, KD; et al. MAGI2 Genetic Variation and Inflammatory Bowel Disease. INFLAMMATORY BOWEL DISEASES 15:75-83(2009).
