MAGEL2
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Official Full Name
MAGE-like 2 -
Overview
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. -
Synonyms
MAGEL2;MAGE-like 2;NDNL1;MAGE-like protein 2;nM15;protein nM15;necdin-like protein 1
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Involved Pathway
MAGEL2 involved in several pathways and played different roles in them. We selected most pathways MAGEL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MAGEL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
MAGEL2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MAGEL2 itself. We selected most functions MAGEL2 had, and list some proteins which have the same functions with MAGEL2. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
MAGEL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGEL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGEL2.
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